Psych-STRATA - A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness
HealthHORIZON-RIAID: 101057454
EC Contribution
€102,764
Consortium Size
31 orgs
Start Year
2022
▶Summary
A key problem in Mental Health is that up to one third of patients suffering from major mental disorders develop resistance against drug therapy. However, patients showing early signs of treatment resistance (TR) do not receive adequate early intensive pharmacological treatment but instead they undergo a stepwise trial-and-error treatment approach. This situation originates from three major knowledge and translation gaps: i.) we lack effective methods to identify individuals at risk for TR early in the disease process, ii.) we lack effective, personalized treatment strategies grounded in insights into the biological basis of TR, and iii.) we lack efficient processes to translate scientific insights about TR into clinical practice, primary care and treatment guidelines. It is the central goal of PSYCH-STRATA to bridge these gaps and pave the way for a shift towards a treatment decision-making process tailored for the individual at risk for TR. To that end, we aim to establish evidence-based criteria to make decisions of early intense treatment in individuals at risk for TR across the major psychiatric disorders of schizophrenia, bipolar disorder and major depression. PSYCH-STRATA will i.) dissect the biological basis of TR and establish criteria to enable early detection of individuals at risk for TR based on the integrated analysis of an unprecedented collection of genetic, biological, digital mental health, and clinical data. ii.) Moreover, we will determine effective treatment strategies of individuals at risk for TR early in the treatment process, based on pan-European clinical trials in SCZ, BD and MDD. These efforts will enable the establishment of novel multimodal machine learning models to predict TR risk and treatment response. Lastly, iii.) we will enable the translation of these findings into clinical practice by prototyping the integration of personalized treatment decision support and patient-oriented decision-making mental health boards.
Consortium (31)
🇩🇪 UNIVERSITAET MUENSTERDE
coordinator ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
partner🇮🇹 Associazione Oasi Maria SS. OnlusIT
partner🇬🇧 CARDIFF UNIVERSITYGB
partner🇩🇪 CHARITE - UNIVERSITAETSMEDIZIN BERLINDE
partner🇩🇪 EUROPEAN RESEARCH SERVICES GMBHDE
partner🇩🇪 FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EVDE
partner🇪🇸 FUNDACIO CENTRE DE REGULACIO GENOMICAES
partner🇪🇸 FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYERES
partner🇪🇸 FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANONES
partner🇧🇪 GLOBAL ALLIANCE OF MENTAL ILLNESS ADVOCACY NETWORKS EUROPE AISBLBE
partner🇸🇪 GOETEBORGS UNIVERSITETSE
partner🇪🇸 HOSPITAL CLINIC DE BARCELONAES
partner🇫🇷 INSTITUT DU CERVEAU ET DE LA MOELLE EPINIEREFR
partner🇩🇪 KAIROS GMBHDE
partner🇩🇪 KARLSRUHER INSTITUT FUER TECHNOLOGIEDE
partner🇧🇪 KATHOLIEKE UNIVERSITEIT LEUVENBE
partner🇬🇧 KING'S COLLEGE LONDONGB
partner🇩🇪 KLINIKUM DER LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHENDE
partner🇩🇪 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHENDE
partner MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
partner🇨🇾 NOVAMECHANICS LIMITEDCY
partner🇬🇷 NOVAMECHANICS MONOPROSOPI IKEGR
partner🇳🇴 OSLO UNIVERSITETSSYKEHUS HFNO
partner🇩🇰 REGION HOVEDSTADENDK
partner🇦🇺 THE UNIVERSITY OF ADELAIDEAU
partner🇮🇹 UNIVERSITA DEGLI STUDI DI BRESCIAIT
partner🇮🇹 UNIVERSITA DEGLI STUDI DI CAGLIARIIT
partner🇳🇱 UNIVERSITAIR MEDISCH CENTRUM UTRECHTNL
partner🇳🇴 UNIVERSITETET I OSLONO
partner🇨🇭 WORLD PSYCHIATRIC ASSOCIATIONCH
partnerProject Results (40)
Source: CORDIS, the EU research results database.
▶Publications (38)
A meta-analysis of polygenic risk scores for mood disorders, neuroticism, and schizophrenia in antidepressant response
Giuseppe Fanelli, Katharina Domschke, Alessandra Minelli, Massimo Gennarelli, Paolo Martini, Marco Bortolomasi, Eduard Maron, Alessio Squassina, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Bernhard T Baune, Alessandro Serretti, Chiara Fabbri
A naturalistic retrospective evaluation of the utility of pharmacogenetic testing based on CYP2D6 e CYP2C19 profiling in antidepressants treatment in a cohort of patients with major depressive disorder
Alessio Squassina, Pasquale Paribello, Marco Pinna, Martina Contu, Claudia Pisanu, Donatella Congiu, Giovanni Severino, Anna Meloni, Andrea Carta, Claudio Conversano, Francesco Mola, Maria Del Zompo, Federico Bernoni d'Aversa, Alessandra Minelli, Massimo Gennarelli, Federica Pinna, Bernardo Carpiniello, Mirko Manchia
A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe
B. T. Baune, S. E. Fromme, M. Aberg, M. Adli, A. Afantitis, I. Akkouh, O. A. Andreassen, C. Angulo, S. Barlati, C. Brasso, P. Bucci, M. Budde, P. Buspavanich, V. Cavone, K. Demyttenaere, C. M. Diaz-Caneja, M. Dierssen, S. Djurovic, M. Driessen, U. W. Ebner-Priemer, J. Engelmann, S. Englisch, C. Fabbri, P. Fossati, H. Fröhlich, S. Gasser, N. Gottlieb, E. Heirman, A. Hofer, O. Howes, L. Ilzarbe, H. Jeung-Maarse, L. V. Kessing, T. D. Kockler, M. Landén, L. Levi, K. Lieb, N. Lorenzon, J. Luykx, M. Manchia, M. Martinez de Lagran, A. Minelli, C. Moreno, A. Mucci, B. Müller-Myhsok, P. Nilsson, C. Okhuijsen-Pfeifer, K. D. Papavasileiou, S. Papiol, A. F. Pardinas, P. Paribello, C. Pisanu, M. -C. Potier, A. Reif, R. Ricken, S. Ripke, P. Rocca, D. Scherrer, C. Schiweck, K. O. Schubert, T. G. Schulze, A. Serretti, A. Squassina, C. Stephan, A. Tsoumanis, E. Van der Eycken, E. Vieta, A. Vita, J. T. R. Walters, D. Weichert, M. Weiser, I. R. Willcocks, I. Winter-van Rossum, A. H. Young, M. J. Ziller
Association of pharmacodynamic genes with treatment outcomes in major depressive disorder: results from a Sardinian cohort
Pasquale Paribello, Mirko Manchia, Marco Pinna, Martina Contu, Davide Orrù, Marco Upali, Sabrina El Kacemi, Ilaria Frau, Federico Suprani, Carolina Corrias, Giulia Somaini, Federica Pinna, Claudia Pisanu, Anna Meloni, Andrea Carta, Claudio Conversano, Francesco Mola, Maria Del Zompo, Lisa Buson, Massimo Gennarelli, Alessandra Minelli, Bernardo Carpiniello, Alessio Squassina
Automated Speech Analysis in Bipolar Disorder: The CALIBER Study Protocol and Preliminary Results
Gerard Anmella, Michele De Prisco, Jeremiah B. Joyce, Claudia Valenzuela-Pascual, Ariadna Mas-Musons, Vincenzo Oliva, Giovanna Fico, George Chatzisofroniou, Sanjeev Mishra, Majd Al-Soleiti, Filippo Corponi, Anna Giménez-Palomo, Laura Montejo, Meritxell González-Campos, Dina Popovic, Isabella Pacchiarotti, Marc Valentí, Myriam Cavero, Lluc Colomer, Iria Grande, Antoni Benabarre, Cristian-Daniel Llach, Joaquim Raduà, Melvin McInnis, Diego Hidalgo-Mazzei, Mark A. Frye, Andrea Murru, Eduard Vieta
Biological markers of sex-based differences in major depressive disorder and in antidepressant response
Rosana Carvalho Silva, Claudia Pisanu, Elisabetta Maffioletti, Valentina Menesello, Marco Bortolomasi, Massimo Gennarelli, Bernhard T Baune, Alessio Squassina, Alessandra Minelli
Digital mental health: challenges and next steps
Katharine A Smith, Charlotte Blease, Maria Faurholt-Jepsen, Joseph Firth, Tom Van Daele, Carmen Moreno, Per Carlbring, Ulrich W Ebner-Priemer, Nikolaos Koutsouleris, Heleen Riper, Stephane Mouchabac, John Torous, Andrea Cipriani
Effect of ketamine and esketamine on RNA expression and its relevance for depression: A systematic review
Claudia Pisanu, Rosana Carvalho Silva, Mattia Meattini, Massimo Gennarelli, Bernhard T. Baune, Alessio Squassina, Alessandra Minelli
Electroconvulsive therapy modulates the interplay between depressive symptoms in difficult-to-treat depression: A longitudinal network analysis
Marialaura Lussignoli, Marco Bortolomasi, Giulia Perusi, Giorgio Pigato, Alessandra Minelli, Fabio Sambataro
Evaluating study designs and treatment outcomes of antidepressant pharmacogenetic clinical trials - Challenges and future perspectives. A critical review
Alessandra Minelli, Stefano Barlati, Bernhard T Baune
Exploring the use of immunomethylomics in the characterization of depressed patients: A proof-of-concept study
Evelien Van Assche, Christa Hohoff, Ecem Su Atil, Sophia M. Wissing, Alessandro Serretti, Chiara Fabbri, Claudia Pisanu, Alessio Squassina, Alessandra Minelli, Bernhard T. Baune
iPSC-modelling reveals genetic associations and morphological alterations of oligodendrocytes in schizophrenia
Man-Hsin Chang, Jan Benedikt Waldeck, Marius Stephan, Nirmal Kannaiyan, Valéria de Almeida, Emanuel Boudriot, Temmuz Karali, Lukas Röll, Laura Fischer, Damianos Demetriou, Nadia Gabellini, Sabrina Galinski, Andrea Schmitt, Sergi Papiol, Daniel Keeser, Peter Falkai, Moritz J. Rossner, Florian J. Raabe
Leukocyte Telomere Length and Mitochondrial DNA Copy Number in Treatment-Resistant Depression and Response to Electroconvulsive Therapy
Alessio Squassina, Claudia Pisanu, Valentina Menesello, Anna Meloni, Donatella Congiu, Mirko Manchia, Pasquale Paribello, Maria Abate, Marco Bortolomasi, Bernhard T. Baune, Massimo Gennarelli, Alessandra Minelli
Mild motor signs and depression: more than just medication side effects?
Antonina Luca, Maria Luca, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Raffaele Zanardi, Raffaella Ferri, Bartolo Lanuzza, Basilio Pecorino, Bernhard T. Baune, Giuseppe Fanelli, Chiara Fabbri, Alessandro Serretti
Mitochondrial DNA copy number is significantly increased in bipolar disorder patients and is correlated with long-term lithium treatment
Anna Meloni, Pasquale Paribello, Marco Pinna, Martina Contu, Raffaella Ardau, Caterina Chillotti, Donatella Congiu, Massimo Gennarelli, Alessandra Minelli, Lisa Buson, Giovanni Severino, Claudia Pisanu, Mirko Manchia, Alessio Squassina
Moving toward precision and personalized treatment strategies in psychiatry
Stefano Comai, Mirko Manchia, Marta Bosia, Alessandro Miola, Sara Poletti, Francesco Benedetti, Sofia Nasini, Raffaele Ferri, Dan Rujescu, Marion Leboyer, Julio Licinio, Bernhard T Baune, Alessandro Serretti
Multi-omics data integration methods and their applications in psychiatric disorders
Anita Sathyanarayanan, Tamara T. Mueller, Mohammad Ali Moni, Katja Schueler, Bernhard T. Baune, Pietro Lio, Divya Mehta, Bernhard T Baune, Mara Dierssen, Bjarke Ebert, Chiara Fabbri, Paolo Fusar-Poli, Massimo Gennarelli, Catherine Harmer, Oliver D. Howes, Joost G.E. Janzing, Pietro Lio, Eduard Maron, Divya Mehta, Alessandra Minelli, Lara Nonell, Claudia Pisanu, Marie-Claude Potier, Filip Rybakowski, Alessandro Serretti, Alessio Squassina, David Stacey, Roos van Westrhenen, Laura Xicota
Neurobiological Perturbations in Bipolar Disorder Compared With Schizophrenia: Evidence From Cell Cultures and Brain Organoids
Ibrahim A. Akkouh, Jordi Requena Osete, Attila Szabo, Ole A. Andreassen, Srdjan Djurovic
Plasma microRNA Levels After Electroconvulsive Therapy in Treatment-Resistant Depressed Patients
Chiara Galbiati, Vincenzo Dattilo, Marco Bortolomasi, Erika Vitali, Maria Abate, Valentina Menesello, Mattia Meattini, Rosana Carvalho Silva, Massimo Gennarelli, Luisella Bocchio Chiavetto, Alessandra Minelli
Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis
Elise Koch, Alexey A. Shadrin, Nadine Parker, Siobhan K. Lock, Robert L. Smith, Oleksandr Frei, Anders M. Dale, Srdjan Djurovic, Espen Molden, Kevin S. O´Connell, Ole A. Andreassen
Predicted plasma proteomics from genetic scores and treatment outcomes in major depression: a meta-analysis
Vincenzo Oliva, Chiara Possidente, Giuseppe Fanelli, Katharina Domschke, Alessandra Minelli, Massimo Gennarelli, Paolo Martini, Marco Bortolomasi, Alessio Squassina, Claudia Pisanu, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Bernhard T Baune, Eduard Vieta, Alessandro Serretti, Chiara Fabbri
Prioritizing Parkinson’s disease risk genes in genome-wide association loci
Lara M. Lange, Catalina Cerquera-Cleves, Marijn Schipper, Georgia Panagiotaropoulou, Alice Braun, Julia Kraft, Swapnil Awasthi, Nathaniel Bell, Danielle Posthuma, Stephan Ripke, Cornelis Blauwendraat, Karl Heilbron
Recommendations for defining treatment outcomes in major psychiatric disorders using real-world data
Elise Koch, Sophie Smart, Guðmundur Einarsson, Anders Kämpe, Lina Jonsson, Maris Alver, Matthew Iveson, Andreas Göteson, Antonio F Pardiñas, Ida E Sønderby, Kevin S O'Connell, Qingqin Li, Yi Lu, Hreinn Stefánsson, Kári Stefánsson, Heather Whalley, Mikael Landén, Michael C O'Donovan, Knut Smerud, Gerard R Dawson, Thomas Werge, Alfonso Buil, Andreas Reif, Lili Milani, Espen Molden, Chiara Fabbri, Alessandro Serretti, James Walters, Cathryn M Lewis, Ole A Andreassen
The future of child and adolescent clinical psychopharmacology: A systematic review of phase 2, 3, or 4 randomized controlled trials of pharmacologic agents without regulatory approval or for unapproved indications
Samuele Cortese, Katherine McGinn, Mikkel Højlund, Alan Apter, Celso Arango, Immaculada Baeza, Tobias Banaschewski, Jan Buitelaar, Josefina Castro-Fornieles, David Coghill, David Cohen, Edna Grünblatt, Pieter J. Hoekstra, Anthony James, Pia Jeppesen, Péter Nagy, Anne Katrine Pagsberg, Mara Parellada, Antonio M. Persico, Diane Purper-Ouakil, Veit Roessner, Paramala Santosh, Emily Simonoff, Dejan Stevanovic, Argyris Stringaris, Benedetto Vitiello, Susanne Walitza, Abraham Weizman, Tamar Wohlfarth, Ian C.K. Wong, Gil Zalsman, Alessandro Zuddas, Carmen Moreno, Marco Solmi, Christoph U. Correll
Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review
Claudia Pisanu, Giovanni Severino, Ilario De Toma, Mara Dierssen, Paolo Fusar-Poli, Massimo Gennarelli, Pietro Lio, Elisabetta Maffioletti, Eduard Maron, Divya Mehta, Alessandra Minelli, Marie-Claude Potier, Alessandro Serretti, David Stacey, Roos van Westrhenen, Laura Xicota, Bernhard T Baune, Alessio Squassina
Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric Disorders
Alessandro Serretti, Bernhard Baune
Anhedonia is associated with a specific depression profile and poor antidepressant response
Antonina Luca, Maria Luca, Siegfried Kasper, Basilio Pecorino, Joseph Zohar, Daniel Souery, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Antonino Messina, Raffaella Zanardi, Raffaele Ferri, Mariangela Tripodi, Bernhard T Baune, Giuseppe Fanelli, Chiara Fabbri, Julien Mendlewicz, Alessandro Serretti
Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder
Philipp Ritter, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kürsat Altınbaş, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P. Behere, Prakash B. Behere, Habte Belete, Tilahun Belete, Gabriel Okawa Belizario, Frank Bellivier, Robert H. Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Şule Bicakci, Harriet Birabwa-Oketcho, Thomas D. Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y. W. Cheung, Silvia Chiesa, Margarita Chanopoulou, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T. Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G. Fiedorowicz, Kostas N. Fountoulakis, Mark A. Frye, Pierre A. Geoffroy, Michael J. Gitlin, Ana Gonzalez-Pinto, John F. Gottlieb, Paul Grof, Bartholomeus C. M. Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T. Isometsä, Maja Ivkovic, Sven Janno, Simon Johnsen, Flávio Kapczinski, Grigorios N. Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara König, Timur L. Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landén, Erik R. Larsen, Rasmus W. Licht, Vera M. Ludwig, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Østergaard Madsen, Simone Alberte Kongstad A. Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Julia Martini, Klaus Martiny, Yuki Mashima, Declan M. McLoughlin, Alie N. R. Meesters, Ybe Meesters, Ingrid Melle, Fátima Meza-Urzúa, Elisabeth Michaelis, Pavol Mikolas, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A. Mozzhegorov, Rodrigo Munoz, Starlin V. Mythri, Fethi Nacef, Ravi K. Nadella, Takako Nakanotani, René Ernst Nielsen, Claire O’Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Johannes Petzold, Andrea Pfennig, Maximilian Pilhatsch, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-apha, Maria Redahan, M. S. Reddy, Andreas Reif, Eva Z. Reininghaus, Jenny Gringer Richards, Janusz K. Rybakowski, Leela Sathyaputri, Angela M. Scippa, Christian Simhandl, Daniel Smith, José Smith, Paul W. Stackhouse, Dan J. Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J. Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E. Vaaler, Eduard Vieta, Biju Viswanath, Carlo Volf, Kai-Jie Yang, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H. Young, Yosra Zgueb, Peter C. Whybrow, Michael Bauer
Biomarkers of treatment-resistant schizophrenia: A systematic review
Claudia Pisanu, Giovanni Severino, Alessandra Minelli, Mara Dierssen, Marie-Claude Potier, Chiara Fabbri, Alessandro Serretti, Massimo Gennarelli, Bernhard T. Baune, Alessio Squassina
Distinct genetic liability profiles define clinically relevant patient strata across common diseases
Trastulla L, Moser S, Jiménez-Barrón LT, Andlauer TFM, von Scheidt M, Budde M, Heilbronner U, Papiol S, Teumer A, Homuth G, Falkai P, Völzke H, Dörr M, Schulze TG, Gagneur J, Iorio F, Müller-Myhsok B, Schunkert H, Ziller MJ.
DNA methylation changes in association with trauma-focused psychotherapy efficacy in treatment-resistant depression patients: a prospective longitudinal study
Rosana Carvalho Silva, Paolo Martini, Christa Hohoff, Stefania Mattevi, Marco Bortolomasi, Valentina Menesello, Massimo Gennarelli, Bernhard T. Baune, Alessandra Minelli
F37. PREDICTED PLASMA PROTEOMICS FROM GENETIC SCORES AND TREATMENT RESPONSE/RESISTANCE IN DEPRESSION
Chiara Fabbri, Vincenzo Oliva, Alessandra Minelli, Massimo Gennarelli, Alessio Squassina, Siegfried Kasper, Daniel Souery, Diego Albani, Raffaella Zanardi, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Bernhard Baune, Eduard Vieta, Alessandro Serretti
IDENTIFYING DRUG TARGETS FOR SCHIZOPHRENIA THROUGH GENE PRIORITIZATION
Karl Heilbron, Julia Kraft, Alice Braun, Swapnil Awasthi, Georgia Panagiotaropoulou, Marijn Schipper, Nathaniel Bell, Danielle Posthuma, Antonio Pardiñas, Stephan Ripke
Polygenic scores of subcortical brain volumes as possible modulators of treatment response in depression
Vincenzo Oliva, Alfonso Martone, Giuseppe Fanelli, Katharina Domschke, Alessandra Minelli, Massimo Gennarelli, Paolo Martini, Marco Bortolomasi, Eduard Maron, Alessio Squassina, Claudia Pisanu, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Bernhard T. Baune, Marie-Claude Potier, Roos van Westrhenen, Filip Rybakowski, Divya Mehta, Mara Dierssen, Joost G.E. Janzing, Pietro Liò, Alessandro Serretti, Chiara Fabbri
Unraveling epigenomic signatures and effectiveness of electroconvulsive therapy in treatment-resistant depression patients: a prospective longitudinal study
Rosana Carvalho Silva, Paolo Martini, Christa Hohoff, Stefania Mattevi, Marco Bortolomasi, Maria Abate, Valentina Menesello, Massimo Gennarelli, Bernhard T. Baune, Alessandra Minelli
W33. A STRATIFIED TREATMENT ALGORITHM IN PSYCHIATRY (PSYCH-STRATA) - FIRST UPDATE FROM AN INTERNATIONAL GWAS OF TREATMENT-RESISTANT DEPRESSION (TRD)
Julia Kraft, Marisol Herrera-Rivero, Stephan Ripke, Chiara Fabbri, Bernhard T. Baune
Genome-wide association studies on Northern Italy isolated populations provide further support concerning genetic susceptibility for major depressive disorder
Vincenzo Dattilo, Sheila Ulivi, Alessandra Minelli, Martina La Bianca, Edoardo Giacopuzzi, Marco Bortolomasi, Stefano Bignotti, Massimo Gennarelli, Paolo Gasparini, Maria Pina Concas
Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count
Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
▶Other Results (1)
Periodic Reporting for period 1 - Psych-STRATA (Psych-STRATA - A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness)
▶Deliverables (1)
Websites, patent fillings, videos etc.