Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness
HORIZON.2.1HORIZON-RIAID: 101057529
EC Contribution
€109,064
Consortium Size
18 orgs
▶Summary
Mental illness runs in families. The FAMILY consortium aims to improve the life of mentally-ill persons with novel prediction models that are based on better understanding the mechanisms of intergenerational transmission of mental illness. The objectives are to improve causal understanding and gain prediction power from the family context by the innovative combination of statistical modelling of genetically informed designs, causal inference, multimodal and multilevel normative prediction, and molecular mapping, brought by world-leading neuroscientific expertise of the consortium, and address key bioethical and social issues raised by the concept of intergenerational risk transmission and risk prediction. FAMILY will bring together the largest existing human (epi)genetic and neuroimaging datasets from both within-family population cohorts and familial high-risk offspring studies, as well as utilise innovative animal models to shed light on pathways underlying intergenerational risk transmission. FAMILY will focus specifically on risk for mood and psychosis symptoms and diagnoses. In-depth causal analyses of how and when risk for mental illness occurs will help identify early risk and resilience factors and predict who is likely to be diagnosed or develop symptoms of mental illness. Advanced insights can uncover new targets for the development of preventive strategies to break the intergenerational cycle of mental illness and to support strengths and resource building. An immediate benefit will be to open direct translational perspectives to mental health care professionals by providing new (family-based) risk prediction tools for the early identification of adults and children at risk and to deliver ethical guidelines to guide its implementation. This will accelerate preventive and treatment intervention in vulnerable families and help target resilience strategies to prevent the transition from health to disease despite high familial risk.
Consortium (18)
🇳🇱 ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAMNL
coordinator🇨🇭 CENTRE HOSPITALIER UNIVERSITAIRE VAUDOISCH
partner🇩🇪 CONCENTRIS RESEARCH MANAGEMENT GMBHDE
partner🇧🇪 EUROPEAN SOCIETY FOR CHILD AND ADOLESCENT PSYCHIATRYBE
partner🇧🇪 EUROPESE FEDERATIE VAN FAMILIEVERENIGINGEN VAN PSYCHIATRISCH ZIEKE PERSONEN IVZWBE
partner🇳🇴 FOLKEHELSEINSTITUTTETNO
partner🇪🇸 FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYERES
partner🇪🇸 FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANONES
partner🇺🇸 HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.US
partner🇪🇸 HOSPITAL CLINIC DE BARCELONAES
partner🇱🇻 LATVIJAS UNIVERSITATELV
partner🇩🇪 LEIBNIZ-INSTITUT FUR RESILIENZFORSCHUNG (LIR) GGMBHDE
partner🇩🇰 REGION HOVEDSTADENDK
partner🇳🇱 STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUMNL
partner🇮🇹 UNIVERSITA DEGLI STUDI DI PERUGIAIT
partner🇨🇭 UNIVERSITA DELLA SVIZZERA ITALIANACH
partner🇨🇭 UNIVERSITAT ZURICHCH
partner🇬🇧 UNIVERSITY COLLEGE LONDONGB
partnerProject Results (84)
Source: CORDIS, the EU research results database.
▶Publications (67)
A father’s legacy: the sperm epigenome, preimplantation development, and paternal environment
Leonard C. Steg, Isabelle M. Mansuy
Are different types of childhood adversities correlated within and across time? A comparison of data on adversity co-occurrence from three longitudinal birth cohort studies
Madison E. Bigler, Isabel K. Schuurmans, Yiwen Zhu, Nitasha Siddique, Nadia Hoffman, Nastassja Koen, Heather J. Zar, Dan J. Stein, Charlotte A.M. Cecil, Erin C. Dunn
Assessing risk for bipolar disorder. Comments on ``Young people at risk for developing bipolar disorder: Two-year findings from the multicenter prospective, naturalistic Early-BipoLife study'' (Martini et al., 2023)
Mireia Solerdelcoll, Inmaculada Baeza, Gisela Sugranyes
Associations between genetic predisposition to mental health problems and academic achievement: a developmental perspective using two population‐based cohorts
Marie‐Pier Larose, Isabel Schuurmans, Edward D. Barker, Liliana Garcia Mondragon, Henning Tiemeier, Irwin Waldman, Charlotte Cecil
Biological pathways underlying the relationship between childhood maltreatment and Multimorbidity: A two-step, multivariable Mendelian randomisation study
Vilte Baltramonaityte, Ville Karhunen, Janine F. Felix, Brenda W.J.H. Penninx, Charlotte A.M. Cecil, Graeme Fairchild, Yuri Milaneschi, Esther Walton
Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders
Nora R. Bakken, Nadine Parker, Laurie J. Hannigan, Espen Hagen, Pravesh Parekh, Alexey Shadrin, Piotr Jaholkowski, Evgeniia Frei, Viktoria Birkenæs, Guy Hindley, Laura Hegemann, Elizabeth C. Corfield, Martin Tesli, Alexandra Havdahl, Ole A. Andreassen
Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls
Kit Melissa Larsen, Júlia Díaz-i-Calvete, Anna Hester Ver Loren van Themaat, Anne Amalie Elgaard Thorup, Kerstin Jessica Plessen, Merete Nordentoft, Hartwig Roman Siebner
Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium
Isabel K. Schuurmans, Rosa H. Mulder, Vilte Baltramonaityte, Alexandra Lahtinen, Fan Qiuyu, Leonardo Melo Rothmann, Marlene Staginnus, Jetro J. Tuulari, S. Alexandra Burt, Claudia Buss, Jeffrey M. Craig, Kirsten A. Donald, Johan G. Eriksson, Janine F. Felix, Tom P. Freeman, Rodrigo Grassi-Oliveira, Anke Huels, Luke W. Hyde, Scott A. Jones, Hasse Karlsson, Linnea Karlsson, Nastassja Koen, Will Lawn, Colter Mitchell, Christopher S. Monk, Michael A. Mooney, Ryan Muetzel, Joel T. Nigg, Síntia Iole Nogueira Belangero, Daniel Notterman, Yi Ying Ong, Tom O’Connor, Kieran J. O’Donnell, Pedro Mario Pan, Tiina Paunio, Peter Ryabinin, Richard Saffery, Giovanni A. Salum, Marc Seal, Tim J. Silk, Dan J. Stein, Ai Peng Tan, Ai Ling Teh, Dennis Wang, Heather Zar, Esther Walton, Charlotte A. M. Cecil
Debate: Child and adolescent mental health services: time to take the lead in prevention of psychosis in youth
Inmaculada Baeza, Gisela Sugranyes
Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia
Simon R. Poortman, Jakub Jamarík, Louise ten Harmsen van der Beek, Nikita Setiaman, Manon H.J. Hillegers, Marjolein E.A. Barendse, Neeltje E.M. van Haren
Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life
Irina Lazar-Contes, Rodrigo G Arzate-Mejia, Deepak K Tanwar, Leonard C Steg, Kerem Uzel, Olivier Ulrich Feudjio, Marion Crespo, Pierre-Luc Germain, Isabelle M Mansuy
Dynastic social processes and the transgenerational transmission of risk and resilience to mental illness: implications for prevention
Andrea Raballo, Michele Poletti, Antonio Preti
Early-life stress and the gut microbiome: A comprehensive population-based investigation
Rosa H. Mulder, Robert Kraaij, Isabel K. Schuurmans, Carlos Frances-Cuesta, Yolanda Sanz, Carolina Medina-Gomez, Liesbeth Duijts, Fernando Rivadeneira, Henning Tiemeier, Vincent W.V. Jaddoe, Janine F. Felix, Charlotte A.M. Cecil
Effects of parental characteristics on the risk of psychopathology in offspring: a 4-year follow-up study
E. De la Serna, D. Moreno, G. Sugranyes, P. Camprodon-Boadas, D. Ilzarbe, A. Bigorra, B. Mora-Maltas, I. Baeza, I. Flamarique, S. Parrilla, C. M. Díaz-Caneja, C. Moreno, R. Borras, C. Torrent, C. Garcia-Rizo, J. Castro-Fornieles
Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior
Marta Schiavon, Birgitte K. Burton, Nicoline Hemager, Aja N. Greve, Katrine S. Spang, Ditte Ellersgaard, Kerstin Jessica Plessen, Jens Richardt M. Jepsen, Anne A. E. Thorup, Thomas Werge, Merete Nordentoft, Ron Nudel
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
Alexander Neumann, Sara Sammallahti, Marta Cosin-Tomas, Sarah E. Reese, Matthew Suderman, Silvia Alemany, Catarina Almqvist, Sandra Andrusaityte, Syed H. Arshad, Marian J. Bakermans-Kranenburg, Lawrence Beilin, Carrie Breton, Mariona Bustamante, Darina Czamara, Dana Dabelea, Celeste Eng, Brenda Eskenazi, Bernard F. Fuemmeler, Frank D. Gilliland, Regina Grazuleviciene, Siri E. Håberg, Gunda Herberth, Nina Holland, Amy Hough, Donglei Hu, Karen Huen, Anke Hüls, Marjo-Riitta Jarvelin, Jianping Jin, Jordi Julvez, Berthold V. Koletzko, Gerard H. Koppelman, Inger Kull, Xueling Lu, Léa Maitre, Dan Mason, Erik Melén, Simon K. Merid, Peter L. Molloy, Trevor A. Mori, Rosa H. Mulder, Christian M. Page, Rebecca C. Richmond, Stefan Röder, Jason P. Ross, Laura Schellhas, Sylvain Sebert, Dean Sheppard, Harold Snieder, Anne P. Starling, Dan J. Stein, Gwen Tindula, Marinus H. van IJzendoorn, Judith Vonk, Esther Walton, Jonathan Witonsky, Cheng-Jian Xu, Ivana V. Yang, Paul D. Yousefi, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Henning Tiemeier, Stephanie J. London, Janine F. Felix, Charlotte Cecil
Ethical and social issues in prediction of risk of severe mental illness: a scoping review and thematic analysis
Ivars Neiders, Signe Mežinska, Neeltje E. M. van Haren
Evocative effects of children's education‐associated genetics on maternal parenting: results from the Norwegian mother, father and child cohort study
Chloe Austerberry, Tetyana Zayats, Angelica Ronald, Elizabeth Corfield, Dinka Smajlagic, Alexandra Havdahl, Ole A. Andreassen, Per Magnus, Pål R. Njølstad, Mona Bekkhus, Pasco Fearon
Fetal Head Growth and Head Circumference at Birth in Children of Women with Psychotic Disorders and Population-Based Controls
Lisanne A E M van Houtum, Dogukan Koc, Sterna A Grundeman, Hans J Duvekot, Hanan El Marroun, Neeltje E M van Haren, Hilmar H Bijma
Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults
Yingjie Shi, Nina Roth Mota, Barbara Franke, Emma Sprooten
Genetic Susceptibility to Neurodevelopmental Conditions Is Associated With Neonatal DNA Methylation Patterns in the General Population: An Individual Participant Data Meta-Analysis
Isabel K. Schuurmans, Dinka Smajlagic, Vilte Baltramonaityte, Anni L.K. Malmberg, Alexander Neumann, Nicole Creasey, Janine F. Felix, Henning Tiemeier, Jean-Baptiste Pingault, Darina Czamara, Katri Raïkkönen, Christian Magnus Page, Robert Lyle, Alexandra Havdahl, Jari Lahti, Esther Walton, Mona Bekkhus, Charlotte A.M. Cecil
Inflammatory markers in pregnancy – identifying drivers in four large cohorts
Frederieke A. J. Gigase, Anna Suleri, Elena Isaevska, Anna-Sophie Rommel, Myrthe G. B. M. Boekhorst, Olga Dmitrichenko, Hanan El Marroun, Eric A. P. Steegers, Manon H. J. Hillegers, Ryan L. Muetzel, Whitney Lieb, Charlotte A. M. Cecil, Victor J. M. Pop, Michael Breen, Veerle Bergink, Lot D. de Witte
Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood
A. G. Allegrini, L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl, J-B. Pingault
Long-term physical health conditions and youth anxiety and depression: Is there a causal link?
Amy Shakeshaft, Jessica R. Mundy, Emil M. Pedersen, Charlotte A. Dennison, Lucy Riglin, Daniela Bragantini, Elizabeth C. Corfield, Ajay K. Thapar, Ole A. Andreassen, Evie Stergiakouli, George Davey Smith, Laurie Hannigan, Katherine L. Musliner, Alexandra Havdahl, Anita Thapar
Mapping prenatal predictors and neurobehavioral outcomes of an epigenetic marker of neonatal inflammation – A longitudinal population-based study
Anna Suleri, Nicole Creasey, Esther Walton, Ryan Muetzel, Janine F. Felix, Liesbeth Duijts, Veerle Bergink, Charlotte A.M. Cecil
Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring
Dogukan Koc, Adriana P. C. Hermans, Bing Xu, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier
Plasma circulating microRNAs and symptoms of depression: Results from a population‐based study
Midas M. Kuilman, Tim Finke, M. Arfan Ikram, Annemarie I. Luik, Alexander Neumann, Charlotte A.M. Cecil, Mohsen Ghanbari
Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology
Kathryn Freeman, Alyson Zwicker, Janice M. Fullerton, Danella M. Hafeman, Neeltje E. M. van Haren, John Merranko, Benjamin I. Goldstein, Emma K. Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergi Mas, Gloria Roberts, Claudio Toma, Peter R. Schofield, Howard J. Edenberg, Holly C. Wilcox, Melvin G. McInnis, Lukas Propper, Barbara Pavlova, Samuel A. Stewart, Eileen M. Denovan-Wright, Guy A. Rouleau, Josefina Castro-Fornieles, Manon H. J. Hillegers, Boris Birmaher, Philip B. Mitchell, Martin Alda, John I. Nurnberger, Rudolf Uher
Prenatal exposure to adverse life events and autism and autistic‐like traits in children in the Norwegian Mother, Father and Child Cohort Study (MoBa)
Aleksandra Kanina, Arvid Sjölander, Miriam I. Martini, Agnieszka Butwicka, Henrik Larsson, Amanda M. Hughes, Márta K. Radó, Mark J. Taylor, Alexandra Havdahl, Helga Ask, Mina A. Rosenqvist
Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches
Ingunn Olea Lund, Laurie J. Hannigan, Helga Ask, Adrian D. Askelund, Laura Hegemann, Elizabeth C. Corfield, Robyn E. Wootton, Yasmin I. Ahmadzadeh, George Davey Smith, Tom A. McAdams, Eivind Ystrom, Alexandra Havdahl
Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study
Nicole Creasey, Isabel Schuurmans, Stella Tsotsi, Serena Defina, Vilte Baltramonaityte, Janine F. Felix, Alexander Neumann, Christian M. Page, Marieke Tollenaar, Mona Bekkhus, Esther Walton, Charlotte Cecil
Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study
Robyn E. Wootton, Kyle Dack, Hannah J. Jones, Lucy Riglin, Paul Madley-Dowd, Carolina Borges, Panagiota Pagoni, Christine Roth, Anne Lise Brantsæter, Elizabeth C. Corfield, Camilla Stoltenberg, Anne-Siri Øyen, George Davey Smith, Helga Ask, Anita Thapar, Evie Stergiakouli, Alexandra Havdahl
Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study
Annalisa Lella, Linda A. Antonucci, Roberta Passiatore, Loredana Bellantuono, Pierluigi Selvaggi, Teresa Popolizio, Guido Di Sciascio, Alessandro Saponaro, Patrizia Ricci, Mario Altamura, Giuseppe Blasi, Antonio Rampino, Chris Vriend, Vince D. Calhoun, Kelly Rootes-Murdy, Aaron L. Goldman, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes, Elena De la Serna, Edith Pomarol-Clotet, Mar Fatjó-Vilas, Raymond Salvador, Andriana Karuk, Paola Fuentes-Claramonte, David C. Glahn, Amanda L. Rodrigue, John Blangero, Lei Wang, Taeyoung Lee, Karolin E. Einenkel, Saskia Hamers, Oliver Gruber, Adrian Preda, Young-Chul Chung, Soyolsaikhan Odkhuu, Corentin Vallée, Paola Dazzan, Machteld Marcelis, Stijn Michielse, Katharina Brosch, Frederike Stein, Igor Nenadić, Benjamin Straube, Florian Thomas-Odenthal, Tilo Kircher, Sean Carruthers, Susan L. Rossell, Phillip J. Sumner, Tamsyn E. Van Rheenen, Caroline Demro, Ian S. Ramsay, Scott R. Sponheim, Rebekka Lencer, Susanne Meinert, Tim Hahn, Udo Dannlowski, Dominik Grotegerd, Mariateresa Ciccarelli, Felice Iasevoli, Giuseppe Pontillo, Godfrey D. Pearlson, Derin Cobia, Fabrizio Piras, Nerisa Banaj, Daniela Vecchio, Marjolein E.A. Barendse, Neeltje E.M. van Haren, Hang Joon Jo, Kang Sim, Yann Quidé, Melissa J. Green, Rachael Slate, Giacomo Cecere, Wolfgang Omlor, Stephanie Homan, Philipp Homan, Sophia I. Thomopoulos, Anna Manzari, Antonello Bellomo, Jessica A. Turner, Theo G.M. van Erp, Paul M. Thompson, Alessandro Bertolino, Giulio Pergola
The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank
María Rodriguez-Ayllon, Alexander Neumann, Amy Hofman, Meike W. Vernooij, Julia Neitzel
The effect of age and sex on brain metabolites: from childhood to adulthood
María Ortuño, Adriana Fortea, Isabel Valli, Emma Muñoz-Moreno, Roger Borràs, Irene Martínez-Serrano, Mireia Masias Bruns, Patricia Camprodon-Boadas, Enric Vilajosana, Lydia Fortea, Joaquim Raduà, Elena de la Serna, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes
The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life
Adrian Dahl Askelund, Laura Hegemann, Andrea G. Allegrini, Elizabeth C. Corfield, Helga Ask, Neil M. Davies, Ole A. Andreassen, Alexandra Havdahl, Laurie J. Hannigan
The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts
Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Henning Tiemeier, Graeme Fairchild, Janine F. Felix, Charlotte A.M. Cecil, Esther Walton
Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age
Xiaolong Guo, Mahnoor Sulaiman, Alexander Neumann, Shijie C. Zheng, Charlotte A.M. Cecil, Andrew E. Teschendorff, Bastiaan T. Heijmans
Youth psychotic experiences: psychometric evaluation and diagnostic associations of the <scp>CAPE</scp> ‐16 in adolescents from the Norwegian Mother, Father and Child Cohort
Viktoria Birkenæs, Pravesh Parekh, Laura Hegemann, Nora R. Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B. Smeland, Ezra Susser, Katrina M. Rodriguez, Markos Tesfaye, Ole A. Andreassen, Alexandra Havdahl, Ida E. Sønderby
Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia
Simon R. Poortman, Marjolein E.A. Barendse, Nikita Setiaman, Martijn P. van den Heuvel, Siemon C. de Lange, Manon H.J. Hillegers, Neeltje E.M. van Haren
Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium
Siwen Wang, Emma Casey, Joanne Sordillo, Sofía Aguilar-Lacasaña, Fernanda Morales Berstein, Richard J. Biedrzycki, Sonia Brescianini, Su Chen, Amy Hough, Elena Isaevska, Woo Jin Kim, Marion Lecorguillé, Sebastian Shaobo Li, Christian M. Page, Jaehyun Park, Stefan Röder, Kristina Salontaji, Gillian Santorelli, Yidan Sun, Sungho Won, Eric Zillich, Lea Zillich, Isabella Annesi-Maesano, S. Hasan Arshad, Mariona Bustamante, Charlotte A. M. Cecil, Hannah R. Elliott, Susan Ewart, Janine F. Felix, Luigi Gagliardi, Siri E. Håberg, Gunda Herberth, Barbara Heude, John W. Holloway, Anke Huels, Wilfried Karmaus, Gerard H. Koppelman, Stephanie J. London, Sunni L. Mumford, Lorenza Nisticò, Maja Popovic, Franca Rusconi, Enrique F. Schisterman, Dan J. Stein, Tabea Send, Henning Tiemeier, Judith M. Vonk, Martine Vrijheid, Joseph Leo Wiemels, Stephanie H. Witt, John Wright, Edwina H. Yeung, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Jorge E. Chavarro, Marie-France Hivert
Characterising developmental dynamics of adult epigenetic clock sites
Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil
Comparing cognition in parents with schizophrenia or bipolar disorder and their 7-year-old offspring
Aja Neergaard Greve, Nicoline Hemager, Erik Lykke Mortensen, Ditte Lou Gantriis, Birgitte Klee Burton, Ditte Ellersgaard, Kerstin J. Plessen, Anne A.E. Thorup, Jens Richardt Møllegaard Jepsen, Merete Nordentoft, Ole Mors, Arndis Simonsen
DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.
Luo M, Walton E, Neumann A, Thio CHL, Felix JF, van IJzendoorn MH, Pappa I, Cecil CAM.
Early detection and intervention through the lens of the neurodevelopmental framework: the salience of developmental years and related services
Andrea Raballo, Michele Poletti, Antonio Preti
Examining longitudinal associations between prenatal exposure to infections and child brain morphology
Anna Suleri, Carolin Gaiser, Charlotte A.M. Cecil, Annet Dijkzeul, Alexander Neumann, Jeremy A. Labrecque, Tonya White, Veerle Bergink, Ryan L. Muetzel
Exposure to prenatal infection and the developmentof internalizing and externalizing problems inchildren: a longitudinal population-based study
Suleri A, Rommel AS, Neumann A, Luo M, Hillegers M, de Witte L, Bergink V, Cecil CAM.
Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study
Kristina Salontaji, Kristine L. Haftorn, Faye Sanders, Christian M. Page, Esther Walton, Janine F. Felix, Mona Bekkhus, Jon Bohlin, Henning Tiemeier, Charlotte A. M. Cecil
Neurobiology and systems biology of stress resilience
Raffael Kalisch, Scott J. Russo, Marianne B. Müller
Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia
Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse, Hugo G. Schnack, Manon H.J. Hillegers, Neeltje E.M. van Haren
Parental education and children’s depression, anxiety, and ADHD traits, a within-family study in MoBa
Amanda M. Hughes, Fartein Ask Torvik, Elsje van Bergen, Laurie J. Hannigan, Elizabeth C. Corfield, Ole A. Andreassen, Eivind Ystrom, Helga Ask, George Davey Smith, Neil M. Davies, Alexandra Havdahl
Participant engagement and involvement in longitudinal cohort studies: qualitative insights from a selection of pregnancy and birth, twin, and family-based population cohort studies
Isabelle Budin-Ljøsne, Nanna A. G. Fredheim, Charlotte Alison Jevne, Bojana Milanovic Kleven, Marie Aline Charles, Janine F. Felix, Robin Flaig, María Paz García, Alexandra Havdahl, Shahid Islam, Shona M. Kerr, Inger Kristine Meder, Lynn Molloy, Susan M. B. Morton, Costanza Pizzi, Aamnah Rahman, Gonneke Willemsen, Diane Wood, Jennifer R. Harris
Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study
Anna Suleri, Kristina Salontaji, Mannan Luo, Alexander Neumann, Rosa H. Mulder, Henning Tiemeier, Janine F. Felix, Riccardo E. Marioni, Veerle Bergink, Charlotte A.M. Cecil
Principal and independent genomic components of brain structure and function
Lennart M. Oblong, Sourena Soheili‐Nezhad, Nicolò Trevisan, Yingjie Shi, Christian F. Beckmann, Emma Sprooten
Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness
Lisanne A. E. M. van Houtum, William F. C. Baaré, Christian F. Beckmann, Josefina Castro-Fornieles, Charlotte A. M. Cecil, Juliane Dittrich, Bjørn H. Ebdrup, Jörg M. Fegert, Alexandra Havdahl, Manon H. J. Hillegers, Raffael Kalisch, Steven A. Kushner, Isabelle M. Mansuy, Signe Mežinska, Carmen Moreno, Ryan L. Muetzel, Alexander Neumann, Merete Nordentoft, Jean-Baptiste Pingault, Martin Preisig, Andrea Raballo, John Saunders, Emma Sprooten, Gisela Sugranyes, Henning Tiemeier, Geeske M. van Woerden, Caroline L. Vandeleur, Neeltje E. M. van Haren
Transgenerational effects of early life stress on the fecal microbiota in mice
Nize Otaru, Lola Kourouma, Benoit Pugin, Florentin Constancias, Christian Braegger, Isabelle M. Mansuy, Christophe Lacroix
Understanding and predicting the intergenerational transmission of mental illness
Nina Karguth, Lisanne A.E.M. van Houtum, Jörg M Fegert, Karen Schlaegel, Andrea Raballo, John Saunders, André Decraene, Neeltje E.M. van Haren
A systematic review of neuroimaging epigenetic research: calling for an increased focus on development
Walton E, Baltramonaityte V, Calhoun V, Heijmans BT, Thompson PM, Cecil CAM.
Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood
Kaupper CS, Blaauwendraad SM, Cecil CAM, Mulder RH, Gaillard R, Goncalves R, Borggraefe I, Koletzko B, Jaddoe VWV.
Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life
Lazar-Contes I, Tanwar DK, Arzate-Meija RG, Steg LC, Feudijo OU, Crespo M, Germain PL, Mansuy IM
Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities
Charlotte A. M. Cecil, Alexander Neumann, Esther Walto
Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development
Hughes DE, Kunitoki K, Elyounssi S, Luo M, Bazer OM, Hopkinson CE, Dowling KF, Doyle AE, Dunn EC, Eryilmaz H, Gilman JM, Holt DJ, Valera EM, Smoller JW, Cecil CAM, Tiemeier H, Lee PH, Roffman JL.
Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.
Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, Blin O, Richardson JC, Bordet R, Lleó A, Alcolea D, Popp J, Marsh TW, Gorijala
On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023).
Cecil CAM, Schuurmans IK.
Remembering through the genome: the role of chromatin states in brain functions and diseases
Arzate-Mejia RG, Mansuy IM.
Risk factors for mood disorders among offspring of parents with bipolar disorder: Findings from a discordant-sibling study
Giacomo FD, Strippoli MF, Castelao E, Amoussou JR, Gholam M, Ranjbar S, Glaus J, Marquet P, Preisig M, Plessen KJ, Vandeleur CL.
The epigenome under pressure: On regulatory adaptation to chronic stress in the brain.
Arzate-Mejia RG, Carullo NVN, Mansuy IM.
▶Deliverables (16)
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▶Other Results (1)
Periodic Reporting for period 1 - FAMILY (Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness)