Boosting the reduction of the environmental impact of pharmaceutical products throughout their entire life cycle.

HORIZON.2.1HORIZON-RIAID: 101057668
EC Contribution
€59,224
Consortium Size
16 orgs
Summary

ETERNAL aims to contribute to sustainable development of pharmaceutical manufacture, use and disposal, by using and promoting full life cycle approaches covering design, manufacture, usage, and disposal, assessing the environmental risks of not only the API and residues/metabolites, but other chemicals and by-products of the production process. This type of approach is essential to take into consideration the types of green manufacturing approach under consideration by the pharmaceutical industry, as evidenced by the range and scope of case studies being undertaken within ETERNAL. Specific application of our risk and life cycle assessment approaches to the ETERNAL case studies is a key element of the proposed work and will provide industry and policymakers with key examples of how whole life cycle assessment may be used to evaluate the changes in environmental impacts expected due to the introduction of green manufacturing processes.

Consortium (16)

Project Results (23)

Source: CORDIS, the EU research results database.

Publications (14)
A New Collaboration to Establish Safe and Sustainable Pharmaceutical Lifecycles by Design
· 2025DOI
Henderson, John; Peeling Robert
Continuous improvement towards environmental protection for pharmaceuticals: advancing a strategy for Europe
Environmental Sciences Europe· 2025DOI
Sam Harrison, Catherine Barnett, Stephen Short, Cansu Uluseker, Patricia V. Silva, Maria D. Pavlaki, Sarah Roberts, Madalena Vieira, Stephen Lofts, Susana Loureiro, David J. Spurgeon
Environmental Toxicology
Environmental Toxicology· 2025DOI
Fábio Campos; Maria D. Pavlaki; Amadeu M. V. M. Soares; Susana Loureiro
Project Eternal Overview Presentation
· 2025DOI
Ferrer Pérez, Pablo; Sebastia-Luna, Paz; Henderson, John
Recovery and reuse of homogeneous palladium catalysts <i>via</i> organic solvent nanofiltration: application in the synthesis of AZD4625
Green Chemistry· 2025DOI
Hui Xiao; William R. F. Goundry; Rhys Griffiths; Yanyue Feng; Staffan Karlsson
SETAC_Pharmaceuticals Strategy for Europe A Call for Continuous Improvement towards Environmental Protection
SETAC Europe 34th Annual Meeting (SETAC), Seville· 2025DOI
Sam Harrison
A framework for early-stage sustainability assessment of innovation projects enabled by weighted sum multi-criteria decision analysis in the presence of uncertainty
Open Research Europe· 2024DOI
John Henderson; Robert Peeling
Assessing the feasibility of Twin Screw Extrusion processing in the development of pharmaceutical products
· 2024DOI
Ficiarà, E.
Optimized used of solvents in Active Pharmaceutical Ingredients production
· 2024DOI
Iacoangeli, T.
Organic Solvent Nanofiltration in Pharmaceutical Applications
Organic Process Research and Development· 2024DOI
Xiaoa, Hui; Feng, Yanyue; Goundry, William R.F.; Karlsson, Staffan
Workshop Output report from an ETERNAL Industry engagement workshop at Making Pharmaceuticals UK Conference programme. Making Pharmaceuticals UK Conference, Coventry, United Kingdom.
Zenodo· 2024DOI
Henderson, J.
"Concept paper on ""compliant-by-design"" key-drivers and roadmap of the possible regulatory pathways or relevant regulatory frameworks for the required ""compliant-by-design"" strategies"
· 2023DOI
Diego Hernandez Pedraza
Integrating Artificial Intelligence and Big Data in Pharmaceutical Development: Ethical Considerations and Legislative Frameworks.
ZenodoDOI
Pedraza, D. H., Nettleton, D., Poch, A., & López de la Cruz, M. (2024).
Laccase‑Mediated Transformation of Trazodone Hydrochloride and Its By‑Products
Reactions in ChemistryDOI
Fabbri, F., Warne, C. M., Cassatella, P., Ruso, D., Doppler, M., Pellis, A., & Guebitz, G. M. (2025).
Deliverables (9)