A PeRsOnalized Prevention roadmap for the future HEalThcare

HealthHORIZON-CSAID: 101057721
EC Contribution
€28,124
Consortium Size
22 orgs
Start Year
2022
Summary

"PROPHET - a PeRsOnalized Prevention roadmap for the future HEalThcare"" will develop a Strategic Research and Innovation Agenda (SRIA) for Personalized Prevention, in order to support the implementation of innovative, sustainable and effective personalized programmes to prevent common chronic diseases. Technological biomedical advances (including omics data and digital tools) make risk stratification at the individual level possible. However, development of Personalized Prevention approaches must be accompanied by healthcare system transition, including citizen engagement, healthcare professional education and addressing organisational, social and legal issues. PROPHET will be centred around stakeholder engagement and the SRIA co-creation process in relation to three main strands of activities: Mapping, Assessment, and Building. Firstly, we will summarize, evaluate and discuss with the relevant stakeholders the extent to which all these new technologies can synergise (Mapping). Secondly, we will design a holistic framework (the PROPHET Framework) that will include all the necessary aspects to appraise Personalized Prevention approaches and their adoption by Public Health Authorities (Assessment). Thirdly, we will support the introduction of Personalised Prevention Programmes by providing guidelines for their design, engaging with healthcare professionals (especially those working with policy makers), and increasing health literacy at the population level on the benefits of Personalized Prevention (Building). PROPHET will liaise with other key current and forthcoming initiatives at EU level, such as ICPerMed, European Partnership (EP) PerMed, the CSA Beyond 1 Million Genomes (B1MG), and the EP on Transforming Health and Care Systems. The consortium consists of 18 beneficiaries and 2 affiliated entities across 12 EU Countries, and a large number of stakeholders already engaged from different Target Groups.""

Consortium (22)

Project Results (39)

Source: CORDIS, the EU research results database.

Publications (18)
A scoping review of the assessment reports of genetic or genomic tests reveals inconsistent consideration of key dimensions of clinical utility
Journal of Clinical Epidemiology· 2025DOI
Angelo Maria Pezzullo, Angelica Valz Gris, Nicolò Scarsi, Diego Maria Tona, Martina Porcelli, Matteo Di Pumpo, Peter Piko, Roza Adany, Pragathy Kannan, Markus Perola, Maria Luis Cardoso, Alexandra Costa, Astrid M. Vicente, Anu Reigo, Mariliis Vaht, Andres Metspalu, Mark Kroese, Roberta Pastorino, Stefania Boccia
Barriers and facilitators for implementing a pharmacogenetic passport: lessons learned from reusing sequencing data
Pharmacogenomics· 2025DOI
Anja H. A. Roelofsen, Loes Lindiwe Kreeftenberg, Carla G. van El, Lidewij Henneman, Tessel Rigter, Daoud Sie, Pierre M. Bet, Martina C. Cornel
Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review
International Journal of Molecular Sciences· 2025DOI
Chantal Babb de Villiers, Elena Plans-Beriso, Chaitanya Erady, Laura Blackburn, Hayley Wilson, Heather Turner, Isla Kuhn, Cristina Barahona-López, Paul Diez-Echave, Orlando Romulo Hernández, Nerea Fernández de Larrea-Baz, Dafina Petrova, Ramon Cierco Jimenez, Pablo Fernández-Navarro, Esther García-Esquinas, Fernando Rodríguez-Artalejo, María José Sánchez, Víctor Moreno, Marina Pollán, Beatriz Perez-Gomez, Mark Kroese
Genomic findings with familial implications: agenda setting in light of mainstreaming
Open Research Europe· 2025DOI
Amicia Phillips, Eva Van Steijvoort, Maria Siermann, Janneke M.L. Kuiper, Álvaro Mendes, Sandrine de Montgolfier, Helle Vendel Petersen, Anna Rosén, Hilde Van Esch, Laurent Pasquier, Danya F. Vears, Christine Patch, Wannes Van Hoof, Ainsley J. Newson, Saskia Bulk, Carla van El, Eline Dancet, Emmanuelle Rial-Sebbag, Colin Mitchell, Pascal Borry
Implementation of genetic tests for disease prevention: challenges in evidence synthesis across clinical utility domains
European Journal of Public Health· 2025DOI
Angelica Valz Gris, Astrid M Vicente, Stefania Boccia
Scanning the horizon of personalized prevention research: an overview of ongoing European funded initiatives
Frontiers in Public Health· 2025DOI
Alessandra Maio, Sara Farina, Tommaso Osti, Salvatore Di Grande, Roberta Pastorino, Stefania Boccia
Sharing behavior and health care utilization following direct-to-consumer genetic testing: a systematic review
Open Research Europe· 2025DOI
Eva Van Steijvoort, Kaatje Goossens, Kenji Demesure, Alexandra Stanczak, Maria Siermann, Pascal Borry
The current landscape of personalised preventive approaches for non-communicable diseases: A scoping review
PLOS ONE· 2025DOI
Sara Farina, Tommaso Osti, Luigi Russo, Alessandra Maio, Nicolò Scarsi, Cosimo Savoia, Abdelrahman Taha, Leonardo Villani, Roberta Pastorino, Stefania Boccia
A Conceptual Model for Health Impact Assessment of Personalized Prevention Policies
European Journal of Public Health· 2024DOI
C Costa, F Lopes, A Costa, M L Cardoso, A V Gris, P Kannan, F Garvão, M Perola, S Boccia, A M Vicente
Barriers to Personalised Prevention: Perspectives from a Multi-Stakeholder Consultation
European Journal of Public Health· 2024DOI
A Costa, M L Cardoso, A Carvalho, T Osti, S Farina, E Flodkvist, A Gyllenberg, S Boccia, A M Vicente
Biomarkers for personalised prevention of chronic diseases: a common protocol for three rapid scoping reviews
Systematic Reviews· 2024DOI
E Plans-Beriso, C Babb-de-Villiers, D Petrova, C Barahona-López, P Diez-Echave, O R Hernández, N F Fernández-Martínez, H Turner, E García-Ovejero, O Craciun, P Fernández-Navarro, N Fernández-Larrea, E García-Esquinas, I Kuhn, V Jiménez-Planet, V Moreno, F Rodríguez-Artalejo, M J Sánchez, M Pollan-Santamaria, L Blackburn, M Kroese, B Pérez-Gómez
Engagement of patients and the public in personalised prevention in Europe using genomic information: a scoping review
Frontiers in Public Health· 2024DOI
Loes Lindiwe Kreeftenberg; Loes Lindiwe Kreeftenberg; Lidewij Henneman; Lidewij Henneman; Johannes C. F. Ket; Martina C. Cornel; Martina C. Cornel; Carla G. van El; Carla G. van El
Indicators of the clinical utility of genetic or genomic testing: a scoping review
European Journal of Public Health· 2024DOI
A Valz Gris, A Pezzullo, T Diego, M Porcelli, M Di Pumpo, N Scarsi, null null, S Boccia
The 1+Million Genomes Maturity Level Model for Genomics in Healthcare
European Journal of Public Health· 2024DOI
A Vicente
The PROPHET project paves the way for personalized prevention in the future healthcare
European Journal of Cancer Prevention· 2024DOI
Roberta Pastorino, Angelo Maria Pezzullo, Tommaso Osti, Roza Adany, Pascal Borry, Floris Barnhoorn, Eva Fadil, Mark Kroese, Andres Metspalu, Beatriz Perez-Gomez, Markus Perola, Daniela Quaggia, Serena Scollen, Mahsa Shabani
Unveiling pharmacogenomics: insights from Portuguese pharmacists on quaternary prevention
European Journal of Public Health· 2024DOI
M L Cardoso, A Costa, C Rasga, A R Marques, A Vicente
Clinician perspectives on policy approaches to genetic risk disclosure in families
Familial Cancer· 2023DOI
Amicia Phillips; Danya F. Vears; Ine Van Hoyweghen; Pascal Borry
Lawfulness in secondary use of health data
Technology and Regulation, Vol 2022 (2022)· 2022DOI
Mahsa Shabani; Sami Yilmaz
Deliverables (20)
Documents, reports
Websites, patent fillings, videos etc.
Documents, reports
Other Results (1)
Periodic Reporting for period 2 - PROPHET (A PeRsOnalized Prevention roadmap for the future HEalThcare)