Next Generation BiOactiVe NAnocoatings

Digital, Industry & SpaceHORIZON-RIAID: 101058554
EC Contribution
€46,991
Consortium Size
15 orgs
Start Year
2022
Summary

NOVA aims to provide a comprehensive approach to antimicrobial coating development by creating an effective feedback loop between coating design, end use and functional/safety testing. This consists of combinatorial optimisation of 4 coating technologies: i) light activated based on: UV up-converters, nanoscale photocatalysts and hydrophobic carbon-based Quantum Dots and ii) contact killing biopolymers (chain-length controlled supramolecular assemblies of polypeptides and polysaccharides). The coatings will be adjusted in a use case driven specifications for having the capacity to coat different substrates in the same environment such as hospitals. In order to guarantee safety for citizens and environment, the coatings will be developed with a Safe and Sustainable by Design (SSbD) approach taking into account the environmental risks. NOVA will develop advanced tissue tests and immunotoxicity tests optimized for coatings to provide tools for the regulatory bodies an in depth analysis of future coatings. For demonstrating practical efficacy, real-life mimicking, innovative antimicrobial tests will be developed. The validated coatings will be developed for commercial exploitation by upscaling using the capacities of the industrial partners. For easier adoption specific coating application devices will be designed within the project. Finally, the experimental data generated within the project together with the historical data of coating developers of the consortium will be used for developing predictive models using machine learning methodologies for expedited coating development methodologies in the future. NOVA aims to bring high efficiency, eco-friendly, stable coatings demonstrated within the project in 4 main use cases (textiles, paints, tactile electronics and frequently touched hard surfaces with high hygienical relevance like e.g. in hospitals and common hygienical relevance in public spaces) which can be then expanded for more widespread utilization.

Consortium (15)

Project Results (40)

Source: CORDIS, the EU research results database.

Publications (35)
A novel and validated 3D-printed method for the consistent and reproducible dry transfer of microorganisms for the determination of antimicrobial surface efficacy
Applied and Environmental Microbiology· 2025DOI
Emma Chareyre, Alexander J. Cunliffe, Peter Askew, Gillian Iredale, Abby Marchant, Andrew P. Dean, James Redfern
Ecotoxicology and Environmental Safety
Ecotoxicology and Environmental Safety· 2025DOI
Philipp Meier; Giacomo Reina; Sandro Lehner; Milijana Jovic; Maria Kovacova; Zdenko Spitalsky; Simone Schulte; Stefan Fischer; Pascal Kock; Peter Neubauer; Peter Wick
Plasma Functionalization Enables Diffusion Control of Reactive Oxygen Species
Small· 2025DOI
Paula Navascués; Flaela Kalemi; Flavia Zuber; Philipp Meier; Ludovica M. Epasto; Michał Góra; Barbara Hanselmann; Svetlana Kucher; Enrica Bordignon; Qun Ren; Giacomo Reina; Dirk Hegemann
Cationic homopolypeptides: A versatile tool to design multifunctional antimicrobial nanocoatings
Materials Today Bio· 2024DOI
Kocgozlu, Leyla; Mutschler, Angela; Tallet, Lorène; Calligaro, Cynthia; Knopf-Marques, Helena; Lebaudy, Eloïse; Mathieu, Eric; Rabineau, Morgane; Gribova, Varvara; Senger, Bernard; Vrana, N. Engin; Lavalle, Philippe
Critical analysis of methods to determine growth, control and analysis of biofilms for potential non-submerged antibiofilm surfaces and coatings
Biofilm· 2024DOI
James Redfern, Alexander J Cunliffe, Darla Goeres, Nuno Azevedo, Joanna Verran
Developing advanced biological models to anticipate possible side effects in next-generation antimicrobial coatings
· 2024DOI
Meier, Philipp; Reina, Giacomo; Kononenko, Veno; Drobne, Damjana; Kurz, Susanne; Spohn, Juliane; Wick, Peter
Evaluating the antibacterial & antifungal efficacy of copper under varying relative humidity
· 2024DOI
Cunliffe, Alexander; Askew, Peter; Iredale, Gillian; Redfern, James
Journal of Interconnection Networks
Advanced Healthcare Materials· 2024DOI
Borges, João; Zeng, Jinfeng; Liu, Xi Qiu; Chang, Hao; Monge, Claire; Garot, Charlotte; Ren, Ke‐feng; Machillot, Paul; Vrana, Nihal E.; Lavalle, Philippe; Akagi, Takami; Matsusaki, Michiya; Ji, Jian; Akashi, Mitsuru; Mano, João F.; Gribova, Varvara; Picart, Catherine
L-31: ANTIBACTERIAL ACTIVITY OF 3D PRINTED THERMOPLASTIC ELASTOMERS FOR BIOMEDICAL APPLICATIONS
· 2024DOI
Spitalsky, Zdenko; Vykydalová, Anna; Švajdlenková, Helena; Kroneková, Zuzana; Kováčová, Mária; Shaalan, Mohamed
L-34: HYDROPHOBIC CARBON QUANTUM DOTS AS ANTIMICROBIAL AGENT IN POLYMER COATINGS AND THEIR ECO-TOXICITY STUDY
· 2024DOI
Kováčová, Mária; Spitalsky, Zdenko; Kononenko, Veno; Annusova, Adriana; Drobne, Damjana; Shaalan, Mohamed
Light-Responsive and Antibacterial Graphenic Materials as a Holistic Approach to Tissue Engineering
ACS Nanoscience Au· 2024DOI
Ferreras, Andrea; Matesanz, Ana; Mendizabal, Jabier; Artola, Koldo; Nishina, Yuta; Acedo, Pablo; Jorcano, José L.; Ruiz, Amalia; Reina, Giacomo; Martín, Cristina
Machine Learning-Based Prediction of Immunomodulatory Properties of Polymers: Toward a Faster and Easier Development of Anti-Inflammatory Biomaterials
Advanced NanoBioMED Research· 2024DOI
Aghilas Akkache, Lisa Clavier, Oleh Mezhenskyi, Kateryna Andriienkova, Thibaut Soubrié, Philippe Lavalle, Nihal Engin Vrana, Varvara Gribova
Methods to assess antibacterial, antifungal and antiviral surfaces in relation to touch and droplet transfer: a review, gap-analysis and suggested approaches
Access Microbiology· 2024DOI
Cunliffe, Alexander J; Marchant, Abby; Askew, Peter; Iredale, Gillian; Redfern, James
Methods to assess antibacterial, antifungal and antiviral surfaces in relation to touch and droplet transfer: a review, gap-analysis and suggested approaches.
Access Microbiology· 2024DOI
Cunliffe, Alexander J.; Askew, Peter; Iredale, Gillian; Marchant, Abby; Redfern, James
Methods to assess porous and non-porous antibacterial, antifungal and antiviral surfaces in relation to touch and droplet transfer in medical and transport applications: a gap analysis and suggested approaches.
Crossref· 2024DOI
Cunliffe, Alexander J; Askew, Peter; Iredale, Gillian; Marchant, Abby; Redfern, James
P-16: THE EXPRESSION OF VIRULENCE GENES IN STAPHYLOCOCCUS AUREUS AFTER CONTACT WITH HCQDS/PDMS
· 2024DOI
Shaalan, Mohamed; Kováčová, Mária; Spitalsky, Zdenko; Spitalska, Eva
Polymer Bulletin
Polymer Bulletin· 2024DOI
Shaalan, Mohamed; Vykydalová, Anna; Švajdlenková, Helena; Kroneková, Zuzana; Marković, Zoran M.; Kováčová, Mária; Špitálský, Zdenko
Reverse Mechanotransduction: Driving Chromatin Compaction to Decompaction Increases Cell Adhesion Strength and Contractility
Nano Letters· 2024DOI
Buisson J., Zhang X., Zambelli T., Lavalle P., Vautier D., Rabineau M.
Antibacterial and antiviral biopolymer-based hydrogels
· 2023DOI
Gribova, Varvara; Lavalle, Philippe; Vrana, Engin; Zebiri, Hadda; Clavier, Lisa
Antibacterial polymer composites based on hydrophobic quantum dots for public transport applications
· 2023DOI
Kovacova, Maria; Shaalan, Mohamed; Zdenko Spitalsky (PISAS)
Antimicrobial carbon quantum dots polymer composites
· 2023DOI
Kováčová, Mária; Špitalský, Zdenko; Shaalan, Mohamed
Blue to UV-C Upconverter
· 2023DOI
Fischer, Stefan; Kock, Pascal; Krusenbaum, Sabine; Schulte, Simone
Multifunkčné Antimikrobiálne Polymérne Nanokompozity s Uhlíkovými Kvantovými Bodkami
· 2023DOI
Maria Kovacova; Zdenko Spitalsky (PISAS)
Nano Today
Nano Today· 2023DOI
Dumit, Verónica I.; Ammar, Ammar; Bakker, Martine; Bañares, Miguel A.; Bossa, Cecilia; Costa, Anna; Cowie, Hilary; Drobne, Damjana; Exner, Thomas E.; Farcal, Lucian; Friedrichs, Steffi; Furxhi, Irini; Grafström, Roland; Haase, Andrea; Himly, Martin; Jeliazkova, Nina; Lynch, Iseult; Maier, Dieter; Noorlander, Cornelle W.; Shin, Hyun Kil; Soler-Illia, Galo J.A.A.; Suarez-Merino, Blanca; Willighagen, Egon; Nymark, Penny
Next Generation BiOactiVe NAnocoatings - NOVA Les scientifiques et les industriels s'unissent pour développer la future génération de technologies de revêtement antimicrobien permettant de créer des environnements plus sains
· 2023DOI
Spohn, Juliane; Stuiver, Anthoine; Espinoza, Sara; Vrana, Engin; Askew, Peter; Redfern, James; Nowack, Bernd; Soubrié, Thibaut; Wick, Peter
Next Generation BiOactiVe NAnocoatings - NOVA Scientists and industry unite to develop the next generation of antimicrobial coating technologies to provide safer environments
· 2023DOI
Vrana, Engin; Espinoza, Sara; Stuiver, Anthoine; Spohn, Juliane; Askew, Peter; Redfern, James; Nowack, Bernd; Soubrié, Thibaut; Wick, Peter
Next Generation BiOactiVe NAnocoatings - NOVA Wetenschappers en de industrie verenigen zich om de volgende generatie antimicrobiële coatingtechnologieën te ontwikkelen om veiligere omgevingen te creëren
· 2023DOI
Espinoza, Sara; Spohn, Juliane; Stuiver, Anthoine; Askew, Peter; Vrana, Engin; Redfern, James; Nowack, Bernd; Soubrié, Thibaut; Wick, Peter
Next Generation BiOactiVe NAnocoatings - NOVA Wissenschaftler:innen und Industrie schließen sich zusammen, um die nächste Generation antimikrobieller Beschichtungstechnologien für eine sicherere Umwelt zu entwickeln
· 2023DOI
Vrana, Engin; Espinoza, Sara; Stuiver, Anthoine; Spohn, Juliane; Askew, Peter; Redfern, James; Nowack, Bernd; Soubrié, Thibaut; Wick, Peter
Permanent coatings: model paint formulations for photocatalysts
· 2023DOI
Claus Schreiner; Dorothea Stübing; Malinn Kastens; Thalea Czarnik
POLYMER COMPOSITES WITH HYDROPHOBIC CARBON QUANTUM DOTS FOR ANTIMICROBIAL APPLICATIONS
· 2023DOI
Kovacova, Maria; Shaalan, Mohamed; Zdenko Spitalsky (PISAS)
Polymer filaments from carbon quantum dots for 3D printing of antimicrobial medical devices
· 2023DOI
Zdenko Spitalsky (PISAS); Frantisek pokrivcak; Eva Spitalska; Maria Kovacova
Preclinical in vitro evaluation of implantable materials: conventional approaches, new models and future directions
Frontiers in Bioengineering and Biotechnology· 2023DOI
Frisch, Emilie; Clavier, Lisa; Belhamdi, Abdessamad; Vrana. Nihal Engin; Lavalle, Philippe; Frisch, Benoit; Heurtault, Beatrice; Gribova, Varvara
Shaping the Future of Antimicrobial Coatings
· 2023DOI
Billig, Melusine; Espinoza, Sara; Vrana, Nihal Engin
Sustainability
Sustainability· 2023DOI
Merve Tunali; Hyunjoo Hong; Luis Mauricio Ortiz-Galvez; Jimeng Wu; Yiwen Zhang; David Mennekes; Barbora Pinlova; Danyang Jiang; Claudia Som; Bernd Nowack
The High Potential of ε-Poly-l-Lysine for the Development of Antimicrobial Biomaterials
Advanced NanoBioMED Research· 2023DOI
Lebaudy E., Guilbaud-Chéreau C., Frisch B., Vrana N. E., Lavalle P
Deliverables (4)
Other Results (1)
Periodic Reporting for period 1 - NOVA (Next Generation BiOactiVe NAnocoatings)