RNA and Cell Biology - from Fundamental Research to Therapies

HORIZON.4.1HORIZON-CSAID: 101059801
EC Contribution
€131,223
Consortium Size
3 orgs
Summary

Polish science, including biomedical research, has made huge advances in the last 30 years. However, the advancement of its fundamental scientific discoveries toward medical or commercial applications still lags behind the top countries, worldwide. This gap stems from the limited experience of Polish researchers in the field of translational research. The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) aims to close this gap by building the capacity to translate basic knowledge into clinical innovations and by introducing an entrepreneurship culture in the scientific environment in Poland. Since its creation, the IIMCB has been a lighthouse of research and management excellence in Poland. Recognising the Institute’s achievements and future potential, the Polish government awarded funding to build an expanded, modern IIMCB headquarters, which will increase our capacity up to 20 research groups. The RACE project under the Teaming programme will help us achieve this reality and successfully upgrade the IIMCB to a world-class translational research Centre of Excellence in RNA and Cell Biology. Together with our Advanced Partners, the Medical Research Council, Human Genetics Unit of the University of Edinburgh (UoE–MRC HGU), and VIB in Belgium, we have identified five Specific Objectives that are key to achieve our goal, namely: recruitment and training of the next generation of entrepreneurial group leaders and researchers (Objectives 1, 2), establishment of modern and self-sustaining Core Facilities adapted to commercial use (Objective 3), implementation of systemic Technology Transfer (Objectives 4) and administrative support (Objective 5). Ultimately, the RACE project will make the IIMCB a reference model in translational research countrywide and elevate the Institute to the top tier of European research centres ready to engage in competitive EU and global biomedical research and innovation projects at the frontiers of science.

Consortium (3)

Project Results (15)

Source: CORDIS, the EU research results database.

Publications (9)
BMC Biology
BMC Biology· 2025DOI
Nathalie Idlin; Sivakumar Krishnamoorthy; Magdalena Wolczyk; Mouad Fakhri; Michal Lechowski; Natalia Stec; Jacek Milek; Pratik Kumar Mandal; Jaroslaw Cendrowski; Christos Spanos; Magdalena Dziembowska; Katarzyna Mleczko-Sanecka; Juri Rappsilber; Gracjan Michlewski
Comprehensive analysis of poly(A) tails in mouse testes and ovaries using Nanopore Direct RNA Sequencing
Scientific Data· 2025DOI
Agnieszka Czarnocka-Cieciura, Michał Brouze, Natalia Gumińska, Seweryn Mroczek, Olga Gewartowska, Paweł S. Krawczyk, Andrzej Dziembowski
Cryo-EM Structure of raiA ncRNA From Clostridium Reveals a New RNA 3D Fold
Journal of Molecular Biology· 2025DOI
Nagendar Goud Badepally, Tales Rocha de Moura, Elżbieta Purta, Eugene F. Baulin, Janusz M. Bujnicki
DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability in mice.
RNA· 2025DOI
Michał Brouze, Marcin Szpila, Areta Magdalena Czerwińska, Wiktor Antczak, Seweryn Mroczek, Tomasz Kuliński, Anna Maria Hojka-Osińska, Dominik Cysewski, Olga Gewartowska, Dorota Adamska, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski
Protocol for the preparation of zebrafish whole heart cell suspension for single-cell analyses
STAR Protocols· 2025DOI
Karim Abu Nahia; Cecilia Lanny Winata
5′ terminal nucleotide determines the immunogenicity of IVT RNAs
Nucleic Acids Research· 2024DOI
Magdalena Wolczyk; Jacek Szymanski; Ivan Trus; Zara Naz; Tola Tame; Agnieszka Bolembach; Nila Roy Choudhury; Karolina Kasztelan; Juri Rappsilber; Andrzej Dziembowski; Gracjan Michlewski
Journal of Biological Chemistry
HSP70 inhibits CHIP E3 ligase activity to maintain germline function in Caenorhabditis elegans.· 2024DOI
Pankaj Thapa; Rupesh V. Chikale; Natalia A. Szulc; Maria-Teodora Pandrea; Agnieszka Sztyler; Khushboo Jaggi; Marta Niklewicz; Remigiusz A. Serwa; Thorsten Hoppe; Wojciech Pokrzywa
Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay
The EMBO Journal· 2024DOI
Agnieszka Czarnocka-Cieciura, Jarosław Poznański, Matti Turtola, Rafał Tomecki, Paweł S Krawczyk, Seweryn Mroczek, Wiktoria Orzeł, Upasana Saha, Torben Heick Jensen, Andrzej Dziembowski, Agnieszka Tudek
Mutation in the mitochondrial chaperone TRAP1 leads to autism with more severe symptoms in males
EMBO Molecular Medicine· 2024DOI
Małgorzata Rydzanicz, Bozena Kuzniewska, Marta Magnowska, Tomasz Wójtowicz, Aleksandra Stawikowska, Anna Hojka, Ewa Borsuk, Ksenia Meyza, Olga Gewartowska, Jakub Gruchota, Jacek Miłek, Patrycja Wardaszka, Izabela Chojnicka, Ludwika Kondrakiewicz, Dorota Dymkowska, Alicja Puścian, Ewelina Knapska, Andrzej Dziembowski, Rafał Płoski, Magdalena Dziembowska
Other Results (4)
Derivative of monophosphate dinucleotide, nucleic acid derivative containing it, and a method of obtaining it
EEN EIWIT DAT SPECIFIEK BINDT AAN RNA/DNA-HYBRIDEN
Periodic Reporting for period 1 - RACE (RNA and Cell Biology - from Fundamental Research to Therapies)
RNA MOLECULES WITH MODIFIED 3' TERMINAL SEQUENCES AND APPLICATION THEREOF
Deliverables (2)
List of appointed members of the CAC and recruited TT and IP managers
Documents, reports
Project website and RACE visual identity
Websites, patent fillings, videos etc.