Strengthening regional stem cells based research for advancement of multi modal innovative strategy for modelling neurodevelopmental disorders

Widening ParticipationHORIZON-CSAID: 101060201
EC Contribution
€11,624
Consortium Size
4 orgs
Start Year
2022
Summary

Neurodevelopmental disorders (NDDs) caused by alterations in early brain development are a group of complex and heterogeneous disorders that give rise to the psychiatric conditions such as autism spectrum disorders, intellectual disability, schizophrenia and bipolar disorder. NDDs have a high socio-economic impact and patients with NDDs and mental health problems are geographically dispersed. Thus, establishment of high capacity regional centres with equivalent research capacity and codes of practice is needed in order to build global research activity. The goals of STREAMLINE are to enhanced strategic networking and reinforce research and innovation potential of the Institute of Molecular Genetics and Genetic Engineering (IMGGE) in order to develop IMGGE as a high capacity hub for research of NDDs in the Western Balkans which is able to integrate with similar centres in Europe. This will be achieved by twinning IMGGE with three top-class research institutions in Europe: Cardiff University, University of Maastricht and Centre for Research and Technology. The project objectives are: a) to enhance the current and scale up the overall strategic networking activities between the IMGGE and internationally-leading European partners and regional partners; b) to raise the research profile of research stuff and scientific attractiveness of IMGGE in the field of NDDs; c) to strengthens research management capacities and administrative skills of the IMGGE staff and d) to become a regional leader in innovations tackling NDDs. Objectives will be achieved through networking, staff exchanges, training, summer schools, symposia, workshops, participation at conferences and dissemination in scientific community, industries and public. Twinning with partners will provide access to new research avenues, creativity, development of new approaches and increased mobility (inwards and outwards) of qualified scientists.

Consortium (4)

Project Results (36)

Source: CORDIS, the EU research results database.

Publications (14)
Additional file 1 of Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review
· 2025DOI
Sylvester, Amy L.; Hensenne, Eva; Ivanov, Dimo; Poser, Benedikt A.; Linden, David E. J.; van Amelsvoort, Thérèse; Vingerhoets, Claudia
Neural excitation/inhibition imbalance and neurodevelopmental pathology in human copy number variant syndromes: a systematic review
Journal of Neurodevelopmental Disorders· 2025DOI
Sylvester, Amy L.; Hensenne, Eva; Ivanov, Dimo; Poser, Benedikt A.; Linden, David E. J.; van Amelsvoort, Therese; Vingerhoets, Claudia
CHARACTERIZATION OF INDUCED PLURIPOTENT STEM CELLS FROM PATIENTS WITH 22Q11.2 DUPLICATION SYNDROME
VII Congress of the serbian genetic society· 2024
Kostić, Jovana; Cuturilo, Goran; Drakulić, Danijela; Petter, Olena; Perić, Mina; Simeunović, Ivana; Stanisavljević Ninković, Danijela; Harwood J., Adrian; Stevanović, Milena; Kovačević-Grujic
ESTABLISHMENT OF A MODEL SYSTEM FOR STUDYING NEURODEVELOPMENTAL DISORDERS USING INDUCED PLURIPOTENT STEM CELLS DERIVED FROM PATIENTS WITH 22Q11.2 DELETION SYNDROME
VII Congress of the serbian genetic society· 2024
Drakulić, Danijela; Harwood, Adrian; Petrakis, Spyros; Linden, David; Stevanović, Milena
PATIENT-DERIVED INDUCED PLURIPOTENT STEM CELLS WITH 22Q11.2 MICRODELETION: A MODEL SYSTEM FOR INVESTIGATING NEURODEVELOPMENTAL DISORDER
VII Congress of the serbian genetic society· 2024
Simeunović, Ivana; Čuturilo, Goran; Kovačević-Grujičić, Nataša; Petter, Olena; Perić, Mina; Kostić, Jovana; Stanisavljević Ninković, Danijela; Harwood J., Adrian; Stevanović, Milena; Draku
Speech Sounds Production, Narrative Skills, and Verbal Memory of Children with 22q11.2 Microdeletion
Children· 2024DOI
Marijana Rakonjac, Goran Cuturilo, Natasa Kovacevic-Grujicic, Ivana Simeunovic, Jovana Kostic, Milena Stevanovic, Danijela Drakulic
STREAMLINE HUB: a high capacity hub for research of neurodevelopmental disorders in the Western Balkan region
Hemijska industrija (Chemical Industry)· 2024
Drakulić, Danijela; Petrakis, Spyros; Harwood, Adrian J.; Linden, David; Lazić, Andrijana; Kovačević-Grujičić, Nataša; Stevanović, Milena
22q11.2 Deletion syndrome as a tool for modelling and research of neurodevelopmental disorders
CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia· 2023
Lazić, Adrijana; Drakulić, Danijela; Kovačević-Grujičić, Nataša; Perić, Mina; Petrakis, Spyros; Linden, David; Harwood, Adrian; Stevanović, Milena
Analysis of cohort of patients with 22q11.2 deletion syndrome - a single-center experience from Serbia
8th Congress of the Serbian Neuroscience Society· 2023
Simeunović, Ivana; Drakulić, Danijela; Cuturilo, Goran; Kovačević-Grujičić, Nataša; Kostić, Jovana; Stevanović, Milena
Application of principal component analysis (PCA) and analytical hierarchy process (AHP) in analysis of articulatory characteristics of phonemes of children with 22q11.2 Deletion Syndrome
4th Belgrade Bioinformatics Conference· 2023
Drakulić, Danijela; Rakonjac, Marijana; Cuturilo, Goran; Kovačević-Grujičić, Nataša; Kušić-Tišma, Jelena; Morić, Ivana; Zukić, Branka; Stevanović, Milena
Establishment of induced pluripotent stem cells from patients with 22q11.2 duplication syndrome as a model system for studying neurodevelopmental disorders
CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia· 2023
Kostić, Jovana; Drakulić, Danijela; Čuturilo, Goran; Petter, Olena; Perić, Mina; Simeunović, Ivana; Harwood J., Adrian; Stevanović, Milena; Kovačević-Grujičić, Nataša
Generation of induced pluripotent stem cells derived from patients with 22q11.2 deletion syndrome as a tool for studying neurodevelopmental disorders
CoMBoS2 – the Second Congress of Molecular Biologists of Serbia, Abstract Book – Trends in Molecular Biology, Special issue 06-08 October 2023, Belgrade, Serbia· 2023
Simeunović, Ivana; Čuturilo, Goran; Kovačević-Grujičić, Nataša; Petter, Olena; Perić, Mina; Kostić, Jovana; Harwood J., Adrian; Stevanović, Milena; Drakulić, Danijela
Genomic and clinical findings in patients with 22q11.2 duplication syndrome
8th Congress of the Serbian Neuroscience Society· 2023
Kostić, Jovana; Drakulić, Danijela; Cuturilo, Goran; Kovačević-Grujičić, Nataša; Simeunović, Ivana; Stevanović, Milena
Intranuclear inclusions of polyQ-expanded ATXN1 sequester RNA molecules
Frontiers in Molecular Neuroscience· 2023DOI
Ioannis Gkekas, Aimilia-Christina Vagiona, Nikolaos Pechlivanis, Georgia Kastrinaki, Katerina Pliatsika, Sebastian Iben, Konstantinos Xanthopoulos, Fotis E. Psomopoulos, Miguel A. Andrade-Navarro, Spy
Deliverables (22)
Documents, reports
Documents, reports
Documents, reports