Functional Nano-Scaffolds for Regenerative Medicine

MSCA (Marie Skłodowska-Curie)HORIZON-TMA-MSCA-DN-JDID: 101072645
EC Contribution
€34,133
Consortium Size
19 orgs
Start Year
2022
Summary

Repair or replacement of tissue and organ functions lost due to age, disease or damage represents one of the most urgent medical needs of our aging society. The NanoReMedi Consortium will contribute to addressing this fundamentally important issue by using a new and efficient scientific approach relying on the design, preparation, characterization and validation of conceptually innovative peptide-based functional nanomaterials for regenerative medicine applications. Specifically, NanoReMedi will tackle three highly relevant case studies: “Tissue engineered vascular grafts to replace damaged peripheral arteries”, “Stem-cell based regenerative medicine for bone and cartilage repair” and “Facing with implantation failure” this last addressed to overcome bacterial severe infections. As an equally important goal, the NanoReMedi Consortium aims to build a world-class doctoral educational model in the field of nanomaterials applied to regenerative nanomedicine, through a strategically designed Academia-Industry interplay. To this end, 6 Beneficiaries, one Associated Partner linked to a beneficiary and 12 non-academic associated partners will join their forces to: i)create a highly innovative research network for training a new generation of 13 Doctoral Candidates (DCs) with strong employment potential, aimed at studying and developing “Functional Nano-Scaffolds for Regenerative Medicine”; ii)establish a robust structure for long-term research cooperation between a pool of leading Universities and Enterprises, for broadening and strengthening the knowledge and skills of DCs accessing the nanoscience-area from adjacent disciplines (such as chemistry, material sciences and bioinformatics); iii)building a solid foundation for long-term European excellence in medical nanotechnology via dissemination of research/training outcomes - through cross-network secondments, Summer Schools workshops and transferable skills modules, and of the best practice generated by NanoReMedi.

Consortium (19)

Project Results (75)

Source: CORDIS, the EU research results database.

Publications (71)
Electrochemical response of α/β-peptides: Influence of the peptide length, stereochemistry and self-assembly on the performance of peptide-based electrochemical sensors
· 2026DOI
Dulce A. Quintana-Romero, Merve Gul, Adrián Fontana-Escartín, M. Luisa Gelmi, Maria M. Pérez-Madrigal, Raffaella Bucci, Carlos Alemán
Plasma-Treated Poly(Lactic Acid): Deciphering the Structure of a Versatile Engineering Material
ACS Omega· 2026DOI
Adrián Fontana-Escartín, Nicolas Simon, Oscar Bertran, Alessandro Contini, Juan Torras, Carlos Alemán
Sol-gel: a bioorthogonal chemistry for customized biomimetic matrices
· 2026DOI
ECHALIER, CECILE, SUBRA, Gilles
Area‐Selective Silicidation: Patterning Metal Silicides from the Bottom Up
Small Structures· 2025DOI
Gabriele Botta, Konstantina Mitropoulou, Evgenii Modin, Manuel Suárez‐Rodríguez, Andrey Chuvilin, Alexander Bittner, Mato Knez
Bioinspired Peptide-Polymer Coatings for Biomedical Applications
· 2025DOI
Nallathambi, Abinaya; GENTA, IDA; Reches, Meital
DNA data storage in electrospun and melt-electrowritten composite nucleic acid-polymer fibers
Materials Today Bio· 2025DOI
Diana Soukarie, Lluis Nocete, Alexander M. Bittner, Ibon Santiago
Influnce of drug-polymer interactions on release kinetics of PLGA and PLAPEG Nanoparticles
· 2025DOI
Gul, Merve; GENTA, IDA; Perez Madrigal, Maria M.; Aleman, Carlos; CHIESA, ENRICA
Insights into Non-Natural Peptide Aggregation in Biocompatible Materials: A Classical and Accelerated Molecular Dynamics Study
· 2025DOI
Ahmed, Saeed
Insights into Non-Natural Peptide Aggregation in Biocompatible Materials: A Classical and Accelerated Molecular Dynamics Study
· 2025DOI
Ahmed, Saeed
New platinum derivatives selectively cause double-strand DNA breaks and death in naïve and cisplatin-resistant cholangiocarcinomas
Journal of Hepatology· 2025DOI
Irene Olaizola, Mikel Odriozola-Gimeno, Paula Olaizola, Francisco J. Caballero-Camino, Noelia Pastor-Toyos, Mireia Tena-Garitaonaindia, Ainhoa Lapitz, Beatriz Val, Amanda R. Guimaraes, Maitane Asensio, Maider Huici-Izagirre, Colin Rae, David de Sancho, Xabier Lopez, Pedro M. Rodrigues, Elisa Herraez, Oscar Briz, Laura Izquierdo-Sanchez, Aitziber Eleta-Lopez, Alexander M. Bittner, Ana Martinez-Amesti, Teresa Miranda, Sumera I. Ilyas, Chiara Braconi, Maria J. Perugorria, Luis Bujanda, Iván Rivilla, Jose J.G. Marin, Fernando P. Cossío, Jesus M. Banales
Self-assembled bifunctional peptide-based coating for biomedical applications
· 2025DOI
Sowmya Chivukula, Enrica Chiesa, Ida Genta, Meital Reches
Self-assembled bifunctional peptide-based coating for biomedical applications
· 2025DOI
Sowmya Chivukula, Enrica Chiesa, Ida Genta, Meital Reches
Self-assembledpeptide-based coating for biomedical applications
· 2025DOI
Sowmya Chivukula, Enrica Chiesa, Ida Genta, Meital Reches
Silylated peptides as building blocks for material synthesis using sol–gel polymerization
Faraday Discussions· 2025DOI
Mehmet B. Karakaplan, Vinay S. Tiwari, Omer Agazani, Cécile Echalier, Gilles Subra, Meital Reches
The tubular cavity of tobacco mosaic virus shields mechanical stress and regulates disassembly
Acta Biomaterialia· 2025DOI
A. Díez-Martínez, P. Ibáñez-Freire, R. Delgado-Buscalioni, D. Reguera, A.M. Bittner, P.J. de Pablo
Aggregation-Induced Enhanced Emission of Tetraphenylethene-phenylalanine Hybrids: Synthesis and Characterization
The Journal of Organic Chemistry· 2024DOI
Antonia I. Antoniou, Michela Pesenti, Stefania Crespi, Dhriti S. Shenoy, Marta Penconi, Alberto Bossi, Sara Pellegrino
Designing self-assembling lipopeptide for tissue regeneration
Proceedings of the 37th European Peptide Symposium· 2024DOI
Dhriti Shenoy, Lauren Roberts, Michela Pesenti, Kaliroi Peqini, Stefania Crespi, Cécile Echalier, Gilles Subra, Sara Pellegrino
Factors influencing initial bacterial adhesion to antifouling surfaces studied by single-cell force spectroscopy
iScience· 2024DOI
Tal Duanis-Assaf, Meital Reches
Multimodal Imaging, Drug Delivery, and On‐Board Triggered Degradation in Soft Capsule Rolling Microrobots
Advanced Intelligent Systems· 2024DOI
David Castellanos‐Robles, Raphaël C. L.‐M. Doineau, Azaam Aziz, Richard Nauber, Song Wu, Silvia Moreno, Konstantina Mitropoulou, Franziska Hebenstreit, Mariana Medina‐Sánchez
Smart Electrospun Nanofibers from Short Peptidomimetics Based on Pyrrolo-pyrazole Scaffold
Biomacromolecules· 2024DOI
Enrica Chiesa, Francesca Clerici, Raffaella Bucci, Francesco Anastasi, Matteo Bottiglieri, Maddalena Patrini, Ida Genta, Alexander M. Bittner, M. Luisa Gelmi
Stereochemical Behavior of Pyrrolo-Pyrazole Peptidomimetics Promoting Phase-Selective Supramolecular Organogels
Gels· 2024DOI
Enrica Chiesa, Francesco Anastasi, Francesca Clerici, Edoardo Mario Lumina, Ida Genta, Sara Pellegrino, Maria Luisa Gelmi
Accelerated Molecular Dynamics for Peptide Folding: Benchmarking Different Combinations of Force Fields and Explicit Solvent Models
Journal of Chemical Information and Modeling· 2023DOI
Crescenzo Coppa, Andrea Bazzoli, Maral Barkhordari, and Alessandro Contini
"Synthesis of a peptidomimetics library for the stabilization of supermagnetic nanoparticles for the transdermal delivery. ""Noncanonical amino acids (ncAAs): Tools for Biological and Biophysical Investigations"
Giulia Servalli, Dulce A. Quintana-Romero, Tommaso Gandini, Raffaella Bucci, Maria Luisa Gelmi
A PRELIMINARY STUDY OF PEPTIDE DECORATED ELECTROSPUN SCAFFOLDS AS VASCULAR GRAFTS
Erdogan Nursu, Shenoy Santosh Dhriti, Chiesa Enrica, Bittner Alexander, Pellegrino Sara, Genta Ida
Antifouling Polyurethane Vascular Grafts to Prevent Implant Failure
Nallathambi, Abinaya, Reches, Meital GENTA, IDA, CHIESA, ENRICA
Bioengineering of lipopeptides for therapeutic applications
Dhriti Shenoy, Michela Pesenti, Kaliroi Peqini, Nicolas Simon, Stefania Crespi, Cécile Echalier, Gilles Subra, Sara Pellegrino
Bioinspired Peptide-Polymer Coatings for Antifouling and Biomedical Applications
Abinaya Nallathambi; Ida Genta; Meital Reches
Cell - laden scaffolds for osteochondral repai
Lauren Roberts, Cécile Echalier , Emeline P errier - Groult , Danièle Nöel, Sara Pellegrino, Gilles Subra
Cell-laden Scaffolds for Osteochondral Repair
Lauren Roberts, Cécile Echalier , Emeline P errier - Groult , Danièle Nöel, Sara Pellegrino, Gilles Subra
Characterization of complex electrospun matrices through hyperspectral Raman imaging
Matteo Bottiglieri, Mohammad Amini, Maria L. Gelmi, Alexander M. Bittner
Design and applications of smart nanocarriers to achieve controlled release of antimicrobial agents for regenerative medicine.
Merve Gul
Designing self-assembling bioactive lipopeptide
Shenoy, D. S., Pellegrino, S., Peqini, K., Pesenti, M., Simon, N., ECHALIER, C., & SUBRA, G.
Develop and Apply Suitable Methods to Perform Molecular Modelling and Perform Conformational Searches and In-Silico Aggregation Studies
Saeed Ahmed, Alessandro Contini, Carlos Enrique Aleman
Diving into the blue: Synthetic methodologies toward aggregation induced fluorescent peptide materials
A.I. Antoniou, M . Pesenti, M. Penconi, D .S. Shenoy, S . Crespi , A . Bossi, S. Pellegrino
Elastin-Like Polypeptide Mimetics: from synthesis to material characterization
Bottiglieri, Matteo
Electrochemical response of α/β-peptides: Influence of the peptide length, stereochemistry and self-assembly on the performance of peptide-based electrochemical sensors
Dulce A. Quintana-Romero, Merve Gul, Adrián Fontana-Escartín, M. Luisa Gelmi, Maria M. Pérez-Madrigal, Raffaella Bucci, Carlos Alemán
Electrospinning of short peptides and characterization through Hyperspectral Raman spectroscopy
Matteo Bottiglieri, Konstantina Mitropoulou, Maria L. Gelmi and Alexander M. Bittner
ENHANCED SAMPLING METHODS FOR PEPTIDE CONFORMATIONAL ANALYSIS: STRENGTHS, LIMITATIONS, AND APPLICATIONS
Crescenzo Coppa, Ahmed Saeed, Alessandro Contini
ESEM and AFM structural characerization of short peptide electrospun fibers
Mitropoulou, Konstantina
ESEM and AFM structural characterization of short peptide electrospun fibers
Mitropoulou, Konstantina
Fabrication of off-the-shelf biodegradable small-caliber Vascular Graftwith improved microbiological and regenerative features
ABINAYA NALLATHAMBI
From Dielectric to Electro-Responsive Thermoplastics: An Approach Based on Electro-Thermal Re-orientation and Charged Gas Activation
ACS Applied Polymer MaterialsDOI
Gul, Merve; Fontana-Escartin, Adrián; Arnau, Marc; Sans, Jordi; Lanzalaco, Sonia,; Armelin, Elaine; Chiesa, Enrica; Genta, Ida; Perez-Madrigal, Maria; Alemán, Carlos
From hybrid peptides to structured bioorganic-inorganic materials
Qassem, Ali
Influnce of drug-polymer interactions on release kinetics of PLGA and PLAPEG Nanoparticles
Merve Gul, Ida Genta, Maria M. Perez Madrigal, Carlos Aleman, Enrica Chiesa
Insights into Non-Natural Peptide Aggregation in Biocompatible Materials: A Classical and Accelerated Molecular Dynamics Study
Ahmed Saeed, Alessandro Contini, Carlos Enrique Alemàn
Investigation of electrochemical response of α/β-peptides: Influence of the peptide length, stereochemistry and self-assembly on the performance of peptide-based electrochemical sensors
Merve Gul, Dulce A. Quintana-Romero, Adrián Fontana- Escartín, Maria Luisa Gelmi, Maria M. Pérez-Madrigal, Enrica Chiesa, Raffaella Bucci , Carlos Alemán
Late-stage peptide functionalization in the development of aggregation induced emissive smart materials
M. Pesenti, A.I. Antoniou, D.S. Shenoy, M. Penconi, S. Crespi, A. Bossi, S. Pellegrino
Manufacturing of composite electrospun VGs for regenerative purposes
Nursu ERDOĞAN, Ida GENTA, Enrica CHIESA, Alexander BITTNER
MANUFACTURING OF SMALL DIAMETER VASCULAR GRAFTS FOR REGENERATIVE PURPOSES
Erdogan Nursu; Shenoy Santosh Dhriti; Chiesa Enrica; Bittner Alexander; Pellegrino Sara; Genta Ida
MSC-laden Scaffolds for Osteochondral Repair
Roberts, L.
Peptide Electrospinning with a Biocompatible Polymer for Biomedical Applications
Nallathambi, Abinaya; Genta Ida, Reches Meital
Peptide-based nanomaterials for tissue regeneration
Nursu Erdogan
PEPTIDE-DECORATED ELECTROSPUN SCAFFOLDS AS VASCULAR GRAFT
Erdogan Nursu; Shenoy Santosh Dhriti; Chiesa Enrica; Bittner Alexander; Pellegrino Sara; Genta Ida
pH-responsive self-assembling IKVAV-derived peptides: in silico and in vitro analysis
Dhriti S. Shenoy, Allegra Ascagni,Michela Pesenti, Antonia I. Antoniou, Alfonso Gautieri, Sara Pellegrino
Playing with Non-Coded Amino Acids to develop Bioinspired Molecular Architectures
Bucci, Raffaella, Maria Luisa Gelmi, Sara Pellegrino
Pure peptide electrospun fibres: synthesis, analysis, dissolution
Konstantina Mitropoulou, Meital Reches, Alexander M. Bittner
Pyrrole-Pyrazole Peptidomimetics: From Cycloaddition to Smart Nanomaterials
M. Bottiglieri, M. L. Gelmi, A. M. Bittner
Self-assembled peptide-based nanofibers for cardiovascular tissue regeneration
Journal of Materials Chemistry BDOI
Dhriti Shenoy, Sowmya Chivukula, Nursu Erdogan, Enrica Chiesa, Sara Pellegrino, Meital Reches, Ida Genta
Self-Assembling Lipopeptide Hydrogels as Functional Scaffolds for Tissue Regeneration
Dhriti Shenoy, Michela Pesenti, Kaliroi Peqini, Emeline Perrier-Groult , Cécile Echalier, Gilles Subra, Sara Pellegrino
Self-assembling lipopeptide hydrogels: Bioactive scaffolds for osteochondral tissue regeneration
Dhriti Shenoy, Michela Pesenti, Kaliroi Peqini, Emeline Perrier-Groult, Cécile Echalier, Gilles Subra, Sara Pellegrino
Self-Assembling Lipopeptide Hydrogels: Building Bioactive Scaffolds for Next- Gen Tissue Regeneration
Dhriti Shenoy, Michela Pesenti, Kaliroi Peqini, Emeline Perrier-Groult, Cécile Echalier, Gilles Subra, Sara Pellegrino
Silylated Biopolymer-based Hydrogels for Osteochondral Repair
Roberts, Lauren
Silylated peptides as building blocks for material synthesis using sol-gel polymerization and self-assembly
Mehmet B. Karakaplan, Vinay S. Tiwari, Omer Agazani, Cécile Echalier, Gilles Subra, Meital Reches
Smart Functionalization of Pyrrole-Pyrazole Peptidomimetics for Tailored Nanomaterials
Bottiglieri, Matteo
Structural characterization of pure peptide electrospun fibers
Konstantina Mitropoulou, Meital Reches, Alexander M. Bittne
Synthesis and applications of TPE-based unnatural amino acids characterized by aggregation induced emission. Creators
M. Pesenti, A.I. Antoniou, D.S. Shenoy, M. Penconi , S. Crespi , A. Bossi, S. Pellegrino
Synthesis of peptidomimetics using Diaryl-beta-Amino acids for the preparation of smart materials
Dulce A. Quintana - Romero , Raff a ella Bucci , Merve Gul, Maria M. Pérez - Madrigal, Carlos Al emán, M . Luisa Gelmi
Synthesis of peptidomimetics using Diaryl-β amino acids for the preparation of smart materials
Dulce A. Quintana - Romero , Raffaella Bucci, Merve Gul, Maria M. Pérez - Madrigal, Carlos Alemán, M . Luisa Gelmi
Synthesis of peptidomimetics using Diaryl-β-amino acids for the preparation of smart materials
Dulce A. Quintana-Romero, R. Bucci, M.L. Gelmi
Synthesis of tetraphenylethene L-phenylalanine derivatives and their application in aggregation induced fluorescent peptide materials Creators
A. I. Antoniou, M. Pesenti, D.S. Shenoy, S. Crespi, M. Penconi, A. Bossi, S. Pellegrino
Ultrathin water layers on viruses
A.M. Bittner, M.A. Iriarte - Alonso , J.H. Melillo , S . Cerveny , S. Chiantia
Deliverables (3)
Other Results (1)
Periodic Reporting for period 1 - NANOREMEDI (Functional Nano-Scaffolds for Regenerative Medicine)