Hybrid neuroscience based on cerebral and muscular information for motor rehabilitation and neuromuscular disorders

Widening ParticipationHORIZON-CSAID: 101079392
EC Contribution
€11,055
Consortium Size
5 orgs
Start Year
2023
Summary

The overall objective of the HybridNeuro CSA is to create the bases and support for long-term, well-structured and integrated research and innovation partnership in the field of hybrid neural-machine interfaces between Slovenia, a widening, developing European country and Sweden, United Kingdom and Spain, well established European countries with high research impact. The addressed hybrid neural-machine interfaces utilize noninvasively recorded cerebral and muscular signals and can be used forobjective assessment, monitoring, and rehabilitation of neuromuscular disorders. The consortium is composed of University of Maribor (UM), Chalmers University of Technology (CUT), Imperial College London (ICL) and Technical University of Catalonia (UPC). All four partners are experts in biomedical signal processing. In the HybridNeuro project, UMs expertise in muscle-machine interfaces (bottom-up approach to neuromuscular investigations) will be complemented by the excellence of CUT, ICL and UPC in emerging research avenue of brain-machine interfaces (top-down approach to neuromuscular investigations) and neurophysiology. High expertise in analysis of cerebral signals, brain-computer interfaces, evoked potentials, brain connectivity, and inverse cerebral modelling makes CUT, ICL and UPC the optimal leading institutions to enhance the scientific and technological capacity of UM.HybridNeuro aims to foster the development of research excellence at UM and in less-developed eastern Slovenian region through a) career forming of early-stage and senior researchers, b) increasing the attractiveness of UM for visiting researchers, c) improving project proposal and management capacity at UM, d) forming new and strengthening old collaborations between industrial, clinical and research institutions in Slovenia and abroad with UM and twinning partners in Sweden, the UK and Spain, and e) increasing the impact and visibility of neuroscience and neuroengineering in Slovenia.

Consortium (5)

Project Results (39)

Source: CORDIS, the EU research results database.

Publications (30)
Assessing SICI Cortical Inhibition With DLPFC TMS‐EEG Using Different ISI Values
Psychophysiology· 2026DOI
Gema Mijancos‐Martínez, Alejandro Bachiller, Inés Fernández‐Linsenbarth, Saúl J. Ruiz‐Gómez, Sergio Romero, Vicente Molina, Miguel Ángel Mañanas
Assessing SICI Cortical Inhibition With DLPFC TMS‐EEG Using Different ISI Values
Psychophysiology· 2026DOI
Gema Mijancos‐Martínez, Alejandro Bachiller, Inés Fernández‐Linsenbarth, Saúl J. Ruiz‐Gómez, Sergio Romero, Vicente Molina, Miguel Ángel Mañanas
Motor unit discharge properties of the vastii muscles and their modulation with contraction level depend on the knee-joint angle
Journal of Applied Physiology· 2026DOI
Tamara Valenčič, Sumiaki Maeo, Stefan Kluzek, Aleš Holobar, Jakob Škarabot, Jonathan P. Folland
A Particle Swarm Optimized Independence Estimator for Blind Source Separation of Neurophysiological Time Series
IEEE Transactions on Biomedical Engineering· 2025DOI
Agnese Grison, Alexander Kenneth Clarke, Silvia Muceli, Jaime Ibáñez, Aritra Kundu, Dario Farina
Acute effects of orofacial, neck, and shoulder relaxation exercises and chewing on soleus H-reflex and motor unit discharge patterns
Journal of Neurophysiology· 2025DOI
Marša Magdič, Aleš Holobar, Matej Kramberger, Matjaž Vogrin, Nina Murks, Anita Fekonja, Miloš Kalc
Assessing Motor Cortical Activity: How Repetitions Impact Motor Execution and Imagery Analysis
Psychophysiology· 2025DOI
Marta Borràs, Sergio Romero, Leidy Y. Serna, Joan F. Alonso, Alejandro Bachiller, Miguel A. Mañanas, Mónica Rojas
Feedback parameters for a closed-loop multiple-input multiple-output model of the upper limb
PLOS Computational Biology· 2025DOI
Ian Syndergaard; Daniel B. Free; Dario Farina; Steven K. Charles
Manual Editing Significantly Improves the Accuracy of Motor Unit Recruitment Threshold and Discharge Rate Assessment from Synthetic HighDensity Surface Electromyograms
34th International Electrotechnical and Computer Science Conference ERK 2025, Portorož, Slovenia· 2025
Nina Murks, Jakob Škarabot, Matej Kramberger, Gašper Sedej, Tamara Valenčič, Christopher D Connelly, Haydn Thomason, Matjaž Divjak and Aleš Holobar
Physiology-Inspired EEG Transformer for Predicting Movement Transitions in Bimanual Tasks
IEEE Journal of Biomedical and Health Informatics· 2025DOI
Tianyu Jia, Haiyang Long, Ciaran McGeady, Xingchen Yang, Francesca Colacrai, Jiarong Wang, Linhong Ji, Chong Li, Dario Farina
The Efficiency of Manual Editing of High-Density Surface Electromyogram Decomposition Depends on the Recorded Muscle and Contraction Level but Less on the Operator’s Experience
IEEE Transactions on Neural Systems and Rehabilitation Engineering· 2025DOI
Nina Murks, Jakob Škarabot, Matej Kramberger, Matjaž Divjak, Gašper Sedej, Tamara Valenčič, Christopher D. Connelly, Haydn Thomason, Aleš Holobar
Twinning for Europe's Competitiveness: Keeping Excellence Connected Across All Regions
· 2025DOI
Cem Öztürk; Hana Owsianková; Tanja Botić; Emilie Trakalova; Blanka Marušincová; Yasemin Ertan; Burcu Kıran; Viera Pechancová; Serena Cogoni; Filiz Onat
Unlocking the full potential of high‐density surface EMG: novel non‐invasive high‐yield motor unit decomposition
The Journal of Physiology· 2025DOI
Agnese Grison, Irene Mendez Guerra, Alexander Kenneth Clarke, Silvia Muceli, Jaime Ibáñez, Dario Farina
WHY TWINNING MATTERS: Factsheets for Policymakers, Research Community, and the Public
· 2025DOI
Trakalova, E., Öztürk, C., Hana, O., Tanja, B., Blanka, M., Yasemin, E., Burcu, K., Viera, P., Serena, C., & Filiz, O.
Activity index outperforms cumulative spike train and amplitude envelopes in surface EMG coherence analysis
ISEK XXIV international conference, Nagoya, Japan, 2024· 2024
Leon Kutoš, Matjaž Divjak and Aleš Holobar
AML-DECODER: Advanced Machine Learning for HD-sEMG Signal Classification—Decoding Lateral Epicondylitis in Forearm Muscles
Diagnostics· 2024DOI
Shirzadi, Mehdi; Rojas Martínez, Mónica Marlene; Alonso López, Joan Francesc; Serna Higuita, Leidy Yanet; Chaler Vilaseca, Joaquim Lluís; Mañanas Villanueva, Miguel Ángel; Marateb, Hamid Reza
Characterization of spinal circuits withhigh density surface electromyography (HDsEMG)
· 2024
Alejandro Pascual, M. Gorkem Ozyurt, Filipe Nascimento, Marco Beato, Robert Brownstone, Martin Koltzenburg and Dario Farina
European Archives of Psychiatry and Clinical Neuroscience
European Archives of Psychiatry and Clinical Neuroscience· 2024DOI
Mijancos Martínez, Gema; Bachiller Matarranz, Alejandro; Fernández Linsenbarth, Inés; Romero Lafuente, Sergio; Serna Higuita, Leidy Yanet; Molina, Vicente; Mañanas Villanueva, Miguel Ángel
Greater motor unit discharge rate during rapid contractions in chronically strength-trained individuals
Journal of Neurophysiology· 2024DOI
Jakob Škarabot, Andrea Casolo, Thomas G. Balshaw, Sumiaki Maeo, Marcel Bahia Lanza, Aleš Holobar, Dario Farina, Jonathan P. Folland, Alessandro Del Vecchio
Hybrid neural interfaces and novel ways of assessing corticomuscular coupling
Dialogues in Neurodegenerative Disorders: Care, communication and biomedical challenges” conference, 2024, Ljubljana, Slovenia.· 2024
Nina Murks, Leon Kutoš, Matej Kramberger, Blanka Zicher, Alejandro Pascual Valdunciel, Dario Farina and Aleš Holobar
Interfacing with motor unit activity using high-density thin-film electrodes
ISEK XXIV international conference 2024, Nagoya, Japan· 2024
Laura Ferrante, Deren Y. Barsakcioglu, Silvia Muceli, Anna Bösendorfer, Benedikt Baumgartner, Oskar Aszmann, Dario Farina
Motor unit discharge rate modulation during isometric contractions to failure is intensity‐ and modality‐dependent
The Journal of Physiology· 2024DOI
Tamara Valenčič, Paul Ansdell, Callum G. Brownstein, Padraig M. Spillane, Aleš Holobar, Jakob Škarabot
Motor Unit Editing Time in High-Density EMG Decomposition Decreases with the Operator's Experience and Pulse-to-Noise Ratio but Does Not Depend on Simulated Muscle
· 2024
Nina Murks, Jakob Škarabot, Matej Kramberger, Gašper Sedej, Tamara Valenčič, Christopher D Connely, Haydn Thomason, Matjaž Divjak and Aleš Holobar
Movement-specific beta-band modulation during movement cancellation in EMG
ISEK XXIV international conference 2024, Nagoya, Japan· 2024
Ciaran McGeady and Dario Farina
On time effectiveness of manual editing of motor unit spike trains
ISEK XXIV international conference, Nagoya, Japan, 2024· 2024
Nina Murks, Jakob Škarabot, Matej Kramberger, Gašper Sedej, Tamara Valenčič, Christopher Connelly, Haydn Thomason, Matjaž Divjak and Aleš Holobar
A new force profile signal for a convex solution of muscle force estimation from electromyographic signals
45th Annual International Conference of the IEEE, Engineering in Medicine and Biology Society 2023· 2023DOI
Mehdi Shirzadi, Arezoo Mirshamsi, Alp Eşrefoğlu, Monica Rojas-Martínez, Hamid Reza Marateb, Miquel Angel Mañanas, and Taian Vieira
Identification of clusters of inseparable motor units from high-density electromyograms of biceps brachii muscle
Proceedings of the Electrotechnical and Computer Science Conference ERK· 2023
Leon Kutoš, Jakob Škarabot, Aleš Holobar
Decoding firings of a large population of human motor units from high‐density surface electromyogram in response to transcranial magnetic stimulation
Journal of PhysiologyDOI
Škarabot, Jakob, Claudia Ammann, Thomas G. Balshaw, Matjaž Divjak, Filip Urh, Nina Murks, Guglielmo Foffani, and Aleš Holobar
High-density neural interfaces and AI-based analysis of neural codes: facts and future prospects
"""Exploring a New Frontier in Brain Research and Neural Codes: Non-invasive Neural Interfaces and AI-driven Decoding of Neural Codes - Present Realities and Future Possibilities"" symposium, 19th European Congress of Clinical Neurophysiology, 9th -12th of S"
Aleš Holobar, Hatice Kumru
On the efficacy of coherence-based assessment of functional coupling between pools of motor units
33th International Electrotechnical and Computer Science Conference ERK 2024, Portorož, Slovenia
Leon Kutoš, Miloš Kalc, Matej Kramberger, Filip Urh and Aleš Holobar
Project Website
HybridNeuro website
Deliverables (9)
Data Management Plan
Documents, reports
Websites, patent fillings, videos etc.
Documents, reports
Websites, patent fillings, videos etc.
Documents, reports