Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe

HORIZON.4.1HORIZON-CSAID: 101087124
EC Contribution
€49,393
Consortium Size
12 orgs
Summary

More than 55 million people worldwide suffer from dementia. Alzheimer disease (AD) is the main cause of this fatal disorder, without any effective disease modifying therapy. Early diagnosis and lifestyle modifications can significantly reduce the costs of care and treatment. There is no conceptual plan implementing modern diagnostic methods in the clinical practice in Czechia and Slovakia. The interaction between universities and private sector developing molecular diagnostic tools is fragmented and lacking. Limited number of talented students are invested in applied AD-focused research. The aim of ADDIT-CE is to interlink two ecosystems in Brno and Bratislava region, embracing the full quadruple helix of innovation driving actors: excellent scientific teams from Masaryk University and Slovak Academy of Sciences, collaborating with top biotech companies: Geneton, BioVendor, and MultiplexDX. Societal actors will be represented by organisations such as Slovak and Czech Alzheimer Societies, Memory Center and Czech Brain Aging Study. The regional government will be involved via Ministry of Health Slovak Republic, and South Moravian Innovation Centre. The joined ecosystems will unite R&I activities focusing on new diagnostic methods and their applications and further interlink academia and business spheres by creating a pilot industrial PhD programme. ADDIT-CE will generate a joint cross-border strategy covering basic and applied research activities aiming on accelerating the development of new tools for preclinical AD diagnostics and lifestyle/pharmacological intervention monitoring. New cutting-edge technologies will be transferred into clinical practise. Results of ADDIT-CE will be used to develop the Slovak National Plan to Combat Dementia, to enrich the Czech National Plan for AD, and will be widely disseminated to end users and society. ADDIT-CE will join forces of the involved ecosystems to revolutionise diagnostic approaches in both countries.

Consortium (12)

Project Results (23)

Source: CORDIS, the EU research results database.

Publications (17)
When Proteins Go MAD—Misfolded, Amplified, Detected: Advances in α-Synuclein Pathophysiology and RT-QuIC Detection
Molecular Neurobiology· 2026DOI
Naďa Labajová, Adam Polák, Ondrej Cehlár, Pavle Križan, Jozef Hritz, Martin Kolisek, Matej Škorvánek, Rostislav Škrabana, Branislav Kovačech, Norbert Žilka
14-3-3ζ protein prevents formation of GSK3β-phosphorylated Tau protein fibrils
International Journal of Biological Macromolecules· 2025DOI
Gytis Kučinskas, Aneta Kozeleková, Kateřina Králová, Viliam Volko, Ondrej Šedo, Jozef Hritz
Characterization of multiple binding sites on microtubule associated protein 2c recognized by dimeric and monomeric 14‐3‐3ζ
The FEBS Journal· 2025DOI
Séverine Jansen, Subhash Narasimhan, Paula Cabre Fernandez, Lucia Iľkovičová, Aneta Kozeleková, Kateřina Králová, Jozef Hritz, Lukáš Žídek
Effects of a 4‐Month Supervised Aerobic‐Strength Training on Cognitive Functions and Clinical State of Patients with Parkinson’s Disease
Alzheimer's & Dementia· 2025DOI
Jozef Ukropec, Lucia Slobodová, Karin Marček Malenovská, Ali Amiri, Michaela Konečná, Igor Straka, Radka Klepochová, Zuzana Košutzká, Martin Krššák, Peter Valkovič, Barbara Ukropcová
Harnessing the power of 19F NMR for characterizing dimerization and ligand binding of 14-3-3 proteins
International Journal of Biological Macromolecules· 2025DOI
Alexandra Náplavová, Aneta Kozeleková, Radek Crha, Angela M. Gronenborn, Jozef Hritz
Supervised aerobic-strength exercise reduces postural sway and improves dual-task gait in Parkinson’s disease
Scientific Reports· 2025DOI
Pavol Martiš, Diana Bzdúšková, Zuzana Košutzká, Lucia Slobodová, Igor Straka, Karin Marček Malenovská, Oksana Mytiai, Veronika Tirpáková, Patrik Konrády, Viera Litváková, Martin Turi Nagy, Zuzana Urbančík, Peter Valkovič, Jozef Ukropec, Barbara Ukropcová, Jana Kimijanová
A closed 3D printed microfluidic device for automated growth and differentiation of cerebral organoids from single‐cell suspension
Biotechnology Journal· 2024DOI
Mario Kandra, Tereza Vanova, Vincent A. Jongen, Jakub Pospíšil, Josef Novák, Václav Chochola, Tomáš Buryška, Zbyněk Prokop, Zdeněk Hodný, Ales Hampl, Dasa Bohaciakova, Josef Jaros
dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments
Angewandte Chemie International Edition· 2024DOI
Kristine Kitoka, Alons Lends, Gytis Kucinskas, Anna Lina Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Zilkova, Branislav Kovacech, Rostislav Skrabana, Jozef Hritz, Kristaps Jaudzems
Hiding in plain sight: Complex interaction patterns between Tau and 14-3-3ζ protein variants
International Journal of Biological Macromolecules· 2024DOI
Radek Crha, Aneta Kozeleková, Alena Hofrová, Lucia Iľkovičová, Norbert Gašparik, Pavel Kadeřávek, Jozef Hritz
Shaping the Future of Preclinical Development of Successful Disease- Modifying Drugs Against Alzheimer's Disease – A Systematic Review of Tau Propagation Models
Acta Neuropathologica Communications· 2024DOI
Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilka
Structures of Oligomeric States of Tau Protein, Amyloid-β, α-Synuclein and Prion Protein Implicated in Alzheimer’s Disease, Parkinson’s Disease and Prionopathies
International Journal of Molecular Sciences· 2024DOI
Ondrej Cehlar, Stefana Njemoga, Marian Horvath, Erik Cizmazia, Zuzana Bednarikova, Exequiel E. Barrera
TLR4-mediated chronic neuroinflammation has no effect on tangle pathology in a tauopathy mouse model
Frontiers in Aging Neuroscience· 2024DOI
Neha Basheer, Muhammad Khalid Muhammadi, Carlos Leandro Freites, Martin Avila, Miraj Ud Din Momand, Natalia Hryntsova, Tomas Smolek, Stanislav Katina, Norbert Zilka
Cerebral organoids derived from patients with Alzheimer´s disease with PSEN1/2 mutations have defective tissue patterning and altered development
Cell Reports· 2023DOI
Tereza Váňová, Jiří Sedmík, Jan Raška, Kateřina Amruz Černá, Petr Tauš, Veronika Pospíšilová, Markéta Nezvedová, Veronika Fedorová, Soňa Kadáková, Hana Klímová, Michaela Capandová, Petra Orviská, Petr Fojtík, Simona Bártová, Karla Plevová, Zdeněk Spáčil
Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues
ChemCatChem· 2023DOI
Gao, Tadeja; Damborsky, Jiri; Janin, Yves L.; Marek, Martin
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate
Molecular Neurodegeneration· 2023DOI
Michal Nemergut; Sergio M. Marques; Lukas Uhrik; Tereza Vanova; Marketa Nezvedova; Darshak Chandulal Gadara; Durga Jha; Jan Tulis; Veronika Novakova; Joan Planas-Iglesias; Antonin Kunka; Anthony Legrand; Hana Hribkova; Veronika Pospisilova; Jiri Sedmik; Jan Raska; Zbynek Prokop; Jiri Damborsky; Dasa Bohaciakova; Zdenek Spacil; Lenka Hernychova; David Bednar; Martin Marek
Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer’s Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control
Stem Cell Research· 2023DOI
Soňa Kadáková, Jan Raška, Hana Hříbková, Veronika Fedorová, Jiří Sedmík, Klára Plešingrová, Kateřina Sheardová, Dáša Bohačiaková
Illuminating the mechanism and allosteric behavior of NanoLuc luciferase
Nature Communications· 2023DOI
Michal Nemergut, Daniel Pluskal, Jana Horáčková, Tereza Šustrová, Jan Tulis, Tomáš Bárta, Racha Baatallah, Glwadys Gagnot, Veronika Nováková, Marika Majerová, Karolina Sedláčková, Sérgio Manuel Marques, Martin Toul, Jiří Damborský, Zbyněk Prokop, David Be
Deliverables (5)
Other Results (1)
Periodic Reporting for period 2 - ADDIT-CE (Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe)