Natural Products Research at Latvian Institute of Organic Synthesis as a driver for Excellence in Innovation

HORIZON.4.1HORIZON-CSAID: 101087181
EC Contribution
€25,000
Consortium Size
2 orgs
Summary

The aim of Natalion is to foster innovation excellence of LIOS by the establishment of the Natural Products Research (NPR) group and implementation of the LIOS Innovation Hub as a complementary structural change. The introduction of new research strands and the structural changes will be achieved under the leadership of ERA Chair holder Dr. Stefano Donadio, an experienced Research and Innovation (R&I) professional. Project objectives:O1 Establishment of the NPR group, including its capacity build-up;O2 Setting up the research directions of the NPR group with a focus on new technologies and products;O3 Integration of activities of the NPR group into internal and external collaborative projects including 3I mobility;O4 Increase competitiveness for attraction of external research funding;O5 Establishment of the LIOS Innovation Hub and its integration into institutional, national and EU ecosystems;O6 Development of a motivating and inclusive institutional environment which fosters innovations and entrepreneurial culture; O7 Enabling institutional compliance to ERA priorities and UN Sustainable Development Goals; O8 Dissemination and exploitation of the results of the NPR group according to PEDR and a communication plan;Establishing the NPR group, the international recruitment, as well as the development of environment, fostering innovations will nurture brain circulation for researchers and innovators. The establishment of the LIOS Innovation Hub and its integration into institutional, national and EU ecosystems will deliver institutional reforms with a focus on innovation. Setting up new research directions and integrating the NPR group into internal and external collaboration networks under the competent guidance of the ERA Chair will leverage excellence of R&I and increase the competitiveness for attraction of external research funding. Better communication of R&I results to society will be achieved by Dissemination and Exploitation of the project results.

Consortium (2)

Project Results (16)

Source: CORDIS, the EU research results database.

Publications (12)
Cyanobacterial Cyclic Peptides Containing <i>cis</i> ‐Pro Conformation
Chemistry – A European Journal· 2026DOI
Jabal Rahmat Haedar, Abujunaid Habib Khan, Christopher R. Coxon, Chin‐Soon Phan
S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis
Communications Chemistry· 2026DOI
Jabal Rahmat Haedar, Abujunaid Habib Khan, Suze Ma, Stefano Donadio, Chin-Soon Phan
Marine Natural Products from Malaysia
Marine Natural Products Research in South-East Asia· 2025DOI
Abujunaid Habib Khan, Chin-Soon Phan
P450 Biarylitide Synthase ShyB Catalyzes the Cross-Link Between His-C2 and Tyr-O4 on the Precursor Peptide
Organic Letters· 2025DOI
Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
P450 Cyptide Synthase KwwB Catalyzes Trp-C5–Trp-N1 Cross-Linking and Accepts Diverse Precursor Peptides
Organic Letters· 2025DOI
Jabal Rahmat Haedar, Gaja Swarna Kumari, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
P450 cyptide synthase MpoB catalyzes the cross-linking of the YPW motif on the precursor peptide
RSC Chemical Biology· 2025DOI
Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Radical SAM cyclophane synthase catalyzes uniform cyclophane formation at multiple Trp-motifs
Tetrahedron Chem· 2025DOI
Abujunaid Habib Khan, Jabal Rahmat Haedar, Anitra Zīle, Chin-Soon Phan
Radical SAM Enzyme WprB Catalyzes Uniform Cross-Link Topology between Trp-C5 and Arg-Cγ on the Precursor Peptide
ACS Chemical Biology· 2025DOI
Abujunaid Habib Khan, Jabal Rahmat Haedar, Vic Kiselov, Viktors Romanuks, Gints Smits, Stefano Donadio, Chin-Soon Phan
Recent advancement of cyanobactins and cyanobactin prenyltransferases from 2021 to 2024
Frontiers in Natural Products· 2025DOI
Abujunaid Habib Khan, Chin-Soon Phan
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Nucleic Acids Research· 2024DOI
Zdouc, M. M. et. al.
Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity
RSC Chemical Biology· 2024DOI
Chin-Soon Phan, Brandon I. Morinaka
The Advancement of Peptides Derived from Kitasatospora
Chemistry & Biodiversity· 2024DOI
Jabal Rahmat Haedar, Abujunaid Habib Khan, Anitra Zīle, Chin-Soon Phan
Deliverables (3)
Other Results (1)
Periodic Reporting for period 1 - Natalion (Natural Products Research at Latvian Institute of Organic Synthesis as a driver for Excellence in Innovation)