ERA Chair for Accelerated Synthetic Chemistry Technologies at Palacký University Olomouc

Widening ParticipationHORIZON-CSAID: 101087318
EC Contribution
€24,991
Consortium Size
1 orgs
Start Year
2023
Summary

To unite a powerful potential of two outstanding research leaders and thus capitalize on their mutual collaboration for reaching the impact none of them would achieve on their own. This is the aim of the ACCELERATOR project. It brings together (1) the world-renowned Professor of Chemistry, inventor and innovator Alexander Dmling as an ERA chair of the Synthetic Group and (2) the Czech Advanced Technology and Research Institute (CATRIN) of Palack University Olomouc (UP), merging three excellent research centres into a unique scientific ecosystem.Better links between R&I actors across European Research Area (ERA) and beyond is a must if Europe is to maximize excellence from across the continent. UP has been pursuing this goal for a long time now. To become a pocket of excellence and an advanced research trend-setter, UP needs to yet (i) enhance the excellence and strengthen its position in ERA; (ii) streamline the R&I commercialization system and establish new industrial partnerships and (iii) foster brain circulation to attract outstanding scientists.So far unconquered issue of automation in synthetic chemistry, innovative compound-based whole-plant-screening technologies for securing food supply, novel antibacterials addressing the challenge of increasing antimicrobial resistance and breakthrough materials for batteries and supercapacitors enabling energy storage from renewable sources are just few challenges awaiting to be solved by the ACCELERATOR. The project that has all prerequisites to rise the ERA Chair's expected impact to its fullness.Project will lead to (1) the increase of the UP's research excellence; (2) institutional changes at UP through strengthening the Innovation & Knowledge Transfer Ecosystem in Olomouc region; (3) improved capability of UP to successfully compete in international research funding; (4) securing the long-term sustainability of the Synthetic chemistry research group after the completion of the project.

Consortium (1)

Project Results (14)

Source: CORDIS, the EU research results database.

Publications (12)
Balinatunfib: A Clinical Oral Small Molecule TNFα Inhibitor
ChemMedChem· 2025DOI
Alexander Dömling, Tad A. Holak
CBL-B – An upcoming immune-oncology target
Expert Opinion on Therapeutic Patents· 2025DOI
Riccardo Fusco, Zeinab Saedi, Imma Capriello, Andriy Lubskyy, Alexander Dömling
Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development
ChemBioChem· 2025DOI
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves
Novel Spirooxindole–Benzofuran Scaffold: Potential Inhibition Against Hepatocellular Carcinoma by Targeting MDM2‐p53 Interaction
ChemistrySelect· 2025DOI
Muhanna K. Al‐Muhanna, Assem Barakat, Mohammad Shahidul Islam, M. Ali, Abdulmajeed Abdullah Alayyaf, Komal Zia, Zaheer Ul‐Haq, Alexander Dömling, Fardous F. El‐Senduny, Farid A. Badria
Precipitation-first synthesis and deep profiling of a 1200-member acrylamide library for covalent drug discovery
Green Chemistry· 2025DOI
Pravin Patil, Emis Ingenito, Riccardo Fusco, Imma Capriello, Zhirui Guan, Anuja Bhalkikar, John Gibbons, Tomas Korba, Stanislav Bashkyrtsev, Oleh Tkachenko, Alexander Dömling
Multicomponent Reactions: A Promising Approach to Isotope Labeling
Synlett· 2024DOI
Alexander Domling, Philip H. Elsinga, Siyu Xiao, Antonio Conte, Bart T. Cornelissen
Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors
JOURNAL OF MEDICINAL CHEMISTRYDOI
Ważyńska Marta A., Butera Roberto, Requesens Marta, Dömling Alexander
Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery
NATURE COMMUNICATIONSDOI
Wang Zefeng, Shaabani Shabnam, Gao Xiang, Dömling Alexander
Exploring Phthalimide as the Acid Component in the Passerini Reaction
ORGANIC LETTERSDOI
Li Jingyao, Zheng Qiang, Dömling Alexander
Innovative synthesis of drug-like molecules using tetrazole as core building blocks
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRYDOI
Li Jingyao, Chandgude Ajay L., Zheng Qiang, Dömling Alexander
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies
CELL DEATH DISCOVERYDOI
Raghuwanshi Sanjeev, Zhang Xu, Arbieva Zarema, Dömling Alexander
The isocyanide SN2 reaction
NATURE COMMUNICATIONSDOI
Patil Pravin Hasuram, Zheng Qiang, Kurpiewska Katarzyna, Dömling Alexander
Other Results (1)
Periodic Reporting for period 1 - ACCELERATOR (ERA Chair for Accelerated Synthetic Chemistry Technologies at Palacký University Olomouc)
Deliverables (1)
Websites, patent fillings, videos etc.