CROSS-SECTORAL ALLIANCE AS THE KEY FOR INNOVATION-DRIVEN BUSINESS SUCCESS OF ESTONIAN AND GREEK REPRODUCTIVE HEALTHCARE

Widening ParticipationHORIZON-CSAID: 101120075
EC Contribution
€29,966
Consortium Size
8 orgs
Start Year
2023
Summary

Constantly decreasing infertility rates and low success rates of in vitro fertilization (IVF) associated with the advanced age of couples create challenges in reproductive medicine. It is crucial to fill the existing gaps to unlock the socioeconomic benefits and boost the commercial viability of reproductive medicine in Europe. The gap in access to excellence is especially witnessed in Widening countries such as Greece and Estonia, where the academic sector is lagging behind, producing a low volume of commercialised innovations and low-quality clinical services. It poses obstacles in creating competitive positions for highly talented specialists with career perspectives and a strong interest in boosting local reproductive medicine, stimulating the brain drain, and minimizing life-long learning opportunities. The contribution of the NESTOR project to solving these challenges is aimed at improving the research and innovation performance of institutions involved in reproductive medicine by boosting the collaboration between industry and academia in Widening and non-Widening countries through cross-sectoral and international mobilities. The NESTOR consortium consists of 8 partners from academic and industry partners from the Netherlands, Greece, and Estonia, ensuring the knowledge transfer and advancement in four key reproductive medicine modalities for the reproductively aged population: personalised medicine solutions, IVF embryo and uterine health studies, and novel non-invasive prenatal testing technologies.In total, NESTOR will engage 23 ERA Talents from the Widening Countries, boosting their research skills, nurturing their innovative and entrepreneurial mindset, and providing them with other transferable skills. The well-tailored secondment methodology is aimed at raising their research profiles, improving their career perspectives and opportunities for life-long learning, which will help reverse the brain drain in the long term.

Consortium (8)

Project Results (16)

Source: CORDIS, the EU research results database.

Publications (14)
Generative artificial intelligence to produce high-fidelity blastocyst-stage embryo images
Human Reproduction· 2024DOI
Ping Cao; Josien Derhaag; Edith Coonen; Han Brunner; Ganesh Acharya; Andres Salumets; Masoud Zamani Esteki
Mitochondrial Venus is more likely to have a lower birthweight
Trends in Endocrinology & Metabolism· 2024DOI
Elina Aleksejeva, Masoud Zamani Esteki, Andres Salumets
ExplORRNet: An interactive web tool to explore stage-wise miRNA expression profiles and their interactions with mRNA and lncRNA in human breast and gynecological cancers
Non-coding RNA Research· 2023DOI
Lawarde, A., Rahmani, E. S., Nath, A., Lavõgina, D., Jaal, J., Salumets, A., & Modhukur, V.
Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss
Nature Medicine· 2023DOI
Essers, R., Lebedev, I.N., Kurg, A. et al.
Aging promotes accumulation of senescent and multiciliated cells in human endometrial epithelium
Human Reproduction OpenDOI
M. Loid, D. Obukhova, K. Kask, A. Apostolov, A. Meltsov, D. Tserpelis, A. van den Wijngaard, S. Altmäe, G. Yahubyan, V. Baev, M. Saare, M. Peters, A. Minajeva, P. Adler, G. Acharya, K. Krjutškov, M. Nikolova, F. Vilella, C.Simon, M. Z. Esteki; A. Salumets
Carboxypeptidase inhibitor LXN expression in endometrial tissue is menstrual cycle Phase-Dependent and is upregulated in endometriotic lesions
GenesDOI
Sarsenova, M., Stepanjuk, A., Saare, M., Kasvandik, S., Soplepmann, P., Mikeltadze, I., Götte, M., Salumets, A., Peters, M.
Clinical-grade whole genome sequencing-based haplarithmisis enables all forms of preimplantation genetic testing
Nature CommunicationsDOI
Anouk E. J. Janssen, Rebekka M. Koeck, Rick Essers, Ping Cao, Wanwisa van Dijk, Marion Drüsedau, Jeroen Meekels, Burcu Yaldiz, Maartje van de Vorst, Bart de Koning, Debby M. E. I. Hellebrekers, Servi J. C. Stevens, Su Ming Sun, Masoud Zamani Esteki
Endometrial Proliferative Phase-Centered View of Transcriptome Dynamics across the Menstrual Cycle
International Journal of Molecular SciencesDOI
Apostolov, A., Naydenov, M., Kalinina, A., Nikolova, M., Saare, M., Aleksejeva, E., Milova, N., Milov, A., Salumets, A., Baev, V., Yahubyan, G.
Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level
Communications BiologyDOI
Sarsenova, M., Lawarde, A., Pathare, A. D. S., Saare, M., Modhukur, V., Soplepmann, P., Terasmaa, A., Käämbre, T., Gemzell-Danielsson, K., Lalitkumar, P. G. L., Salumets, A., Peters, M.
Epidemiologically relevant phthalates affect human endometrial cells in vitro through cell specific gene expression changes related to the cytoskeleton and mitochondria
Reproductive ToxicologyDOI
Visser, N., Silva, A. V., Tarvainen, I., Damdimopoulos, A., Davey, E., Roos, K., Björvang, R. D., Kallak, T. K., Lager, S., Lavogina, D., Laws, M., Piltonen, T., Salumets, A., Flaws, J. A., Öberg, M., Velthut-Meikas, A., Damdimopoulou, P., Olovsson, M.
Exploring Immunome and microbiome interplay in reproductive health: current knowledge, challenges, and novel diagnostic tools
Seminars in Reproductive MedicineDOI
Lingasamy, P., Modhukur, V., Mändar, R., Salumets, A.
Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids
Environment InternationalDOI
Varik, I., Zou, R., Bellavia, A., Rosenberg, K., Sjunnesson, Y., Hallberg, I., Holte, J., Lenters, V., Van Duursen, M., Pedersen, M., Svingen, T., Vermeulen, R., Salumets, A., Damdimopoulou, P., Velthut-Meikas, A.
Stanniocalcin protein expression in female reproductive organs: literature review and public cancer database analysis
EndocrinologyDOI
Khatun, M., Modhukur, V., Piltonen, T. T., Tapanainen, J. S., Salumets, A.
Towards Metric-Driven Difference Detection between Receptive and Nonreceptive Endometrial Samples Using Automatic Histology Image Analysis
Applied SciencesDOI
Raudonis, V., Bartasiene, R., Minajeva, A., Saare, M., Drejeriene, E., Kozlovskaja-Gumbriene, A., Salumets, A.
Other Results (1)
Periodic Reporting for period 1 - NESTOR (CROSS-SECTORAL ALLIANCE AS THE KEY FOR INNOVATION-DRIVEN BUSINESS SUCCESS OF ESTONIAN AND GREEK REPRODUCTIVE HEALTHCARE)
Deliverables (1)
Websites, patent fillings, videos etc.