Decellularised Extracellular Carpets for the Innovative Production of Human Engineered Replicates

The major roadblock in the commercialisation of cell-derived products is the prolonged ex vivo culture period required to develop them. Macromolecular crowding (MMC), a biophysical phenomenon that increases the kinetics of biochemical reactions and biological processes by several orders of magnitude, allows for the accelerated development of cell-derived products. This project will exploit MMC in the development of cell-derived products in 2 technical and 3 commercial work-packages, increasing the international competitiveness of European-based biotech industries and creating new employment, markets and revenue. This 18-months interdisciplinary and intersectoral project will train 1 post-doctoral researcher at the forefront of scientific research and technological innovation. The project will be carried out at University College Dublin, Ireland’s largest university, one of Europe’s leading research-intensive universities and in the top 1 % universities world-wide.