MUlti-spectral Scattering matrix for Enhanced skin imaging

During the ERC REMINISCENCE project, we developed a new microscope whose performances exceed our initial expectations. Based on a reflection matrix approach of wave imaging, this device called DeepInsight provides an unprecedented imaging performance. It allows non-invasive, label-free, real-time and three-dimensional imaging of tissues with a 1 mm-penetration depth at a 500 nm-resolution. Beyond the structural information provided by standard reflectivity images, it also enables quantitative imaging of tissues by mapping biomarkers such as the refractive index, tissue dynamics or scattering strength. This patented innovation thus represents a paradigm shift in label-free microscopy. In the framework of this project, we want to investigate its extremely promising potential for dermatology and cosmetics industry. Our proposed solution overcomes the fundamental limitations of existing microscopes (confocal / OCT) in terms of penetration depth, resolution and 3D frame rate. It will be a turning point for the early detection of melanoma, which remains a blind spot for current technologies. Beyond this specific problem, its real time capabilities will be exploited for non-invasive angiography in order to identify subsurface vascular and structural features known to be associated with numerous skin diseases. Following the PoC project, we plan to establish a start-up company to further develop the microscope and market it to hospitals and cosmetics industry.