Twinning Approach for Computational MRI Technology and Innovation EXcellence in Turkey

Widening ParticipationHORIZON-CSAID: 101159624
EC Contribution
€14,910
Consortium Size
3 orgs
Start Year
2024
Summary

This project will uniquely combine the skills of European physicists, engineers, and clinicians to create the consortium Twinning Approach for Computational MRI Technology and Innovation EXcellence in Trkiye (TACTIX). TACTIX aims to enhance the scientific excellence and innovation capacity of Bogazii Universitesi (BU, Dr. E. ztrk Ik, Trkiye) in the field of computational magnetic resonance imaging (MRI) through a collaboration with two leading European institutions; FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV (Fraunhofer, Prof. Dr. M. Gnther, Germany) and the STICHTING AMSTERDAM UMC (AUMC, Prof. Dr. F. Barkhof, The Netherlands). TACTIX aims to elevate BU to the level of the other two TACTIX partners and create a long-lasting collaboration through education, mentoring, and a joint research project in line with the goals of the work programme topic Twinning Bottom-Up.TACTIX will design an MRI research and development program for MSc and PhD students and integrate it into the teaching platform of the European University NeurotechEU, of which BU is a partner. TACTIX will organize summer schools, winter workshops, and research visits for ECRs. Additionally, exchanges and mentoring will enhance the research excellence and management capacity of BUs senior researchers and administrative staff. TACTIX will organize a joint research project on multiple sclerosis, a chronic yet incurable disease affecting over 400.000 individuals in the EU. TACTIX will implement a novel MRI method to detect more subtle blood-brain barrier (BBB) integrity changes than the current clinical MRI protocol allows. BBB MRI could serve as a biomarker for monitoring insidious episodes of progression independent of relapse activity, potentially allowing for earlier intervention to preserve cognitive function. TACTIX will widely engage stakeholders via peer-reviewed publications, conferences, a project website, social media, and podcasts for lay audiences, including MS patients.

Consortium (3)

Project Results (20)

Source: CORDIS, the EU research results database.

Publications (14)
Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden
NeuroImage: Clinical· 2026DOI
Beatriz E. Padrela, Sandra Tecelão, Bjørn-Eivind Kirsebom, Oliver Geier, Mario Tranfa, Federico Masserini, Markus H. Sneve, Maksim Slivka, Emilie Sogn Falch, Lene Pålhaugen, Amnah Mahroo, Klaus Eickel, David L. Thomas, Matthias Günther, Per Selnes, Atle Bjørnerud, Kristine B. Walhovd, Anders M. Fjell, Frederik Barkhof, Jan Petr, Tormod Fladby, Henk J.M.M. Mutsaerts
Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL
Neuroradiology· 2025DOI
Yeva Prysiazhniuk, Rui Duarte Armindo, Sasha Alexander, Michael Moseley, Kristen W. Yeom, Jakub Otáhal, Martin Kynčl, Elizabeth Tong, Jan Petr, Moss Y. Zhao, Gary K. Steinberg
Application of BBB-ASL in MS: Initial Experience.
Book of Abstracts· 2025
Cetin AI, Turhan G, Van Nederpelt DR, Emekli AS, Mahroo A, Padrela BE, Konstandin S, Honkiss DC, Breutigam N-J, Keil V, Barkhof F, Eickel K, Mutsaerts H-J, Günther M, Kaya D, Dincer A, Petr J, Ozturk-Isik E.
Comparative evaluation of single- and multi-delay arterial spin labeling MRI in preterm neonates
NeuroImage· 2025DOI
Yeva Prysiazhniuk, Sasha Alexander, Rui Duarte Armindo, Elizabeth Tong, Kristen W Yeom, Jakub Otáhal, Martin Kynčl, Michael Moseley, Jan Petr, Moss Y Zhao, Gary K Steinberg
Comparing One-Stage and Two-Stage Model Fitting Approaches in Multi-TE ASL for Blood-Brain Barrier Permeability Assessment.
International Society for Magnetic Resonance in Medicine 2025 Proceedings· 2025
Mahroo A, Eickel K, Günther M.
Harmonizing T1w MRI scans with HACA3 reduces between-scanner volume differences while preserving sensitivity to MS-related atrophy.
Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)· 2025
van Nederpelt, D., Hays, S., Brouwer, I., Strijbis, E., Zuo, L., Moraal, B., Jasperse, B., Mutsaerts, H.-J., Petr, J., Killestein, J., Schoonheim, M., Barkhof, F., Kuijer, J., Vrenken, H.
Identifying MS subtypes using MRI-based machine learning.
Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)· 2025
Bianchi, A., Cortese, R., Battaglini, M., Eshaghi, A., Battaglia, G., Luchetti, L., Sforazzini, F., Gentile, G., Cacciante, F., Leoncini, M., Barkhof, F., Bellenberg, B., Bisecco, A., Bodini, B., Cagol, A., Calabrese, M., Calvi, A., Colato, E., et al.
Intracranial volume loss and skull thickening in metachromatic leukodystrophy and multiple sclerosis.
Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)· 2025
Vorst, G., Wolf, N., van Nederpelt, D., Barkhof, F., van der Knaap, M., Schoonheim, M., Strijbis, E., Pouwels, P.
Longitudinal atrophy measures in MS differ between scanners: implications for trials and clinical implementation.
Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)· 2025
van Nederpelt, D., Brouwer, I., Bos, L., Strijbis, E., Moraal, B., Jasperse, B., Mutsaerts, H.-J., Petr, J., Killestein, J., Schoonheim, M., Barkhof, F., Kuijer, J., Vrenken, H.
Machine Learning-Based IDH Mutational Subgroup Classification in Gliomas Using Cerebral Blood Flow and BBB-ASL Exchange Times.
Book of Abstracts ESMRMB 2025 Online 41st Annual Scientific Meeting 8–11 October 2025.· 2025
Turhan G, Cetin AI, Cur OY, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam N-J, Mutsaerts H-J, Danyeli AE, Ozduman K, Eickel K, Keil V, Günther M, Petr J, Dincer A, Ozturk-Isik E.
Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age
Imaging Neuroscience· 2025DOI
Mathijs B.J. Dijsselhof, Candace Moore, Saba Amiri, Mervin Tee, Saima Hilal, Christopher Chen, Bert-Jan H. van den Born, Wibeke Nordhøy, Ole A. Andreassen, Lars T. Westlye, Nishi Chaturvedi, Alun D. Hughes, David M. Cash, Jonathan M. Schott, Carole H. Sudre, Frederik Barkhof, Joost P.A. Kuijer, Francesca Biondo, James H. Cole, Henk J.M.M. Mutsaerts, Jan Petr
Perfusion and Time of Exchange Measurements in IDH Mutational Subgroups of Gliomas Using BBB-ASL.
International Society for Magnetic Resonance in Medicine 2025 Proceedings· 2025
Turhan G, Çetin Aİ, Padrela BE, Mahroo A, Konstandin S, Hoinkiss DC, Breutigam NJ, Keil V, Danyeli AE, Ozduman K, Eickel K, Mutsaerts HJMM, Günther M, Petr J, Dincer A, Ozturk-Isik E.
The role of network connectivity and transcriptomic vulnerability in shaping gray matter atrophy in multiple sclerosis.
Multiple Sclerosis Journal, 31(3_suppl), 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)· 2025
Barrantes-Cepas, M., Steenwijk, M. D., van Nederpelt, D., Koubiyr, I., Tranfa, M., Lorenzini, L., Vrenken, H., Killestein, J., Strijbis, E., Barkhof, F., Schoonheim, M., Pontillo, G.
Voxelwise T2 Corrected Multi-TE ASL in Meningiomas: Initial Experience.
International Society for Magnetic Resonance in Medicine 2025 Proceedings· 2025
Cetin AI, Turhan G, Mahroo A, Padrela BE, Konstandin S, Hoinkiss DC, Breutigam NJ, Keil V, Danyeli AE, Ozduman K, Eickel K, Mutsaerts H, Günther M, Dincer A, Petr J, Ozturk-Isik E.
Deliverables (6)
Websites, patent fillings, videos etc.
Websites, patent fillings, videos etc.
Websites, patent fillings, videos etc.
Websites, patent fillings, videos etc.
Websites, patent fillings, videos etc.